Phenotypes associated with this allele

• Allele Symbol: Nmur2^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:4358245
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nmur2^tm1Dgen/Nmur2^tm1Dgen	B6N.Cg-Nmur2^tm1Dgen	MGI:4358252

Genotype
MGI:4358252

hm1

• Allelic Composition: Nmur2^tm1Dgen/Nmur2^tm1Dgen
• Genetic Background: B6N.Cg-Nmur2^tm1Dgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:152371 )

• when fed a high fat diet and/or treated with Nmu

decreased circulating glucose level ( J:152371 )

• when fed regular chow

decreased circulating leptin level ( J:152371 )

• when fed a high fat diet

abnormal response/metabolism to endogenous compounds ( J:152371 )

• mice treated with acute central administration of Nmu or Nms fail to exhibit additional anorectic actions unlike similarly treated wild-type mice

• mice treated with acute central administration of Nmu fail to exhibit increased grooming behavior and motor activity as in similarly treated wild-type mice

• when fed a high fat diet, mice treated with chronic central infusion administration gain less weight than similarly treated wild-type mice and do not exhibit an increase in core body temperature

growth/size/body

decreased lean body mass ( J:152371 )

• when fed a high fat diet

decreased body weight ( J:152371 )

• beginning at 3 weeks when fed regular chow or a high fat diet

slow postnatal weight gain ( J:152371 )

• when fed regular chow or a high fat diet

decreased susceptibility to diet-induced obesity ( J:152371 )

• when fed a high fat diet and/or treated with Nmu

behavior/neurological

decreased food intake ( J:152371 )

• when fed regular chow or a high fat diet

adipose tissue

decreased total body fat amount ( J:152371 )

• when fed regular chow or a high fat diet