Phenotypes associated with this allele

• Allele Symbol: Tg(TXNRD2,COMT,ARVCF)1Nhir
• Allele Name: transgene insertion 1, Noboru Hiroi
• Allele ID: MGI:4358257
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(TXNRD2,COMT,ARVCF)1Nhir/0	B6.FVB-Tg(TXNRD2,COMT,ARVCF)1Nhir	MGI:4358324

Genotype
MGI:4358324

tg1

• Allelic Composition: Tg(TXNRD2,COMT,ARVCF)1Nhir/0
• Genetic Background: B6.FVB-Tg(TXNRD2,COMT,ARVCF)1Nhir

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:152368 )

N • social behavior, anxiety-related responses, thigmotaxis, immobility on suspension by the tail and startle reflex are not different from controls

N • mice show a tendency toward lower levels of motor activity compared to wild-type controls but differences were not significant at 1, 2, or 5 months

abnormal discrimination learning ( J:152368 )

• mutants show shorter latency to reach a rewarded arm on an L maze (enhanced incentive learning) on initial 4 days of training compared to wild-type mice at 1 and 2 months of age

• in a rewarded alternation paradigm, mutants and wild-type showed equivalent performance but in a delayed rewarded alternation test, mutants show impaired performance at 2 months of age, but not at 1 month in contrast to wild-type mice which showed improved performance at 2 months

impaired spatial working memory ( J:152368 )

• mice show impaired performance in delayed reward alternation, suggesting a deficit in spatial working memory; short term retention of working memory is normal

homeostasis/metabolism

increased brain catechol O-methyltransferase activity ( J:152368 )

• catechol-O-methyltransferase activity is around 2-fold higher in the prefrontal cortex, hippocampus, and striatum than in wild-type controls

nervous system

nervous system phenotype ( J:152368 )

N • at 5 months of age prepulse inhibition is not different from controls