All Phenotypes Nanos3<tm2.1(cre)Ysa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nanos3^{tm2.1(cre)Ysa}
targeted mutation 2.1, Yumiko Saga
MGI:4358405

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dnaaf11^tm1.1Hmd/Dnaaf11^tm1.1Hmd Nanos3^{tm2.1(cre)Ysa}/Nanos3⁺	involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj	MGI:6285736
cn2	Nanos3^{tm2.1(cre)Ysa}/Nanos3⁺ Pofut1^tm1Ysa/Pofut1^tm1.1Ysa	involves: C3H/HeNJcl * C57BL/6NCrlj * C57BL/6NJcl * CBA/JNCrlj	MGI:5426709
cn3	Exoc7^em1Utr/Exoc7^em1Utr Nanos3^{tm2.1(cre)Ysa}/Nanos3⁺	involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:7640139

Allelic Composition	Dnaaf11^tm1.1Hmd/Dnaaf11^tm1.1Hmd Nanos3^{tm2.1(cre)Ysa}/Nanos3⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnaaf11^tm1.1Hmd mutation (0 available); any Dnaaf11 mutation (26 available)
Nanos3^{tm2.1(cre)Ysa} mutation (1 available); any Nanos3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

immotile sperm ( J:258369 )

• sperm were completely immotile

cellular

immotile sperm ( J:258369 )

• sperm were completely immotile

Allelic Composition	Nanos3^{tm2.1(cre)Ysa}/Nanos3⁺ Pofut1^tm1Ysa/Pofut1^tm1.1Ysa
Genetic Background	involves: C3H/HeNJcl * C57BL/6NCrlj * C57BL/6NJcl * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nanos3^{tm2.1(cre)Ysa} mutation (1 available); any Nanos3 mutation (28 available)
Pofut1^tm1.1Ysa mutation (0 available); any Pofut1 mutation (22 available)
Pofut1^tm1Ysa mutation (0 available); any Pofut1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:183324 )

N	• in 8-week old males, external morphology of the testes, histology of seminiferous tubules, and number of sperm in epididymides are normal; when bred to wild-type females, fecundity is similar to controls

Allelic Composition	Exoc7^em1Utr/Exoc7^em1Utr Nanos3^{tm2.1(cre)Ysa}/Nanos3⁺
Genetic Background	involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Exoc7^em1Utr mutation (0 available); any Exoc7 mutation (28 available)
Nanos3^{tm2.1(cre)Ysa} mutation (1 available); any Nanos3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

azoospermia ( J:347251 )

• germ cells absent from lumen of virtually all seminiferous tubules at age 10 weeks

abnormal spermatocyte morphology ( J:347251 )

• spermatocyte aggregation at age 10 weeks

reproductive system

azoospermia ( J:347251 )

• germ cells absent from lumen of virtually all seminiferous tubules at age 10 weeks

abnormal spermatocyte morphology ( J:347251 )

• spermatocyte aggregation at age 10 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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