About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		F2rl1tm2Cgh
targeted mutation 2, Shaun R Coughlin
MGI:4358416
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		F2rtm2Cgh/F2r+
F2rl1tm2Cgh/F2rl1+ 		involves: 129S4/SvJae * C57BL/6 MGI:4438083
cx2
 		F2rtm1.1Cgh/F2rtm1.1Cgh
F2rl1tm2Cgh/F2rl1tm2Cgh
Tg(Tek-F2r)1Cgh/0 		involves: 129S4/SvJae * C57BL/6 MGI:4438100


Genotype
MGI:4438083
cx1
Allelic
Composition		 F2rtm2Cgh/F2r+
F2rl1tm2Cgh/F2rl1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm2Cgh mutation (0 available); any F2rl1 mutation (60 available)
F2rtm2Cgh mutation (0 available); any F2r mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
incomplete rostral neuropore closure ( J:157446 )
• 22% of embryos from double heterozygous by double null crosses have open hindbrain neuropores at 9.5 days post coitus (dpc)

nervous system
incomplete rostral neuropore closure ( J:157446 )
• 22% of embryos from double heterozygous by double null crosses have open hindbrain neuropores at 9.5 days post coitus (dpc)




Genotype
MGI:4438100
cx2
Allelic
Composition		 F2rtm1.1Cgh/F2rtm1.1Cgh
F2rl1tm2Cgh/F2rl1tm2Cgh
Tg(Tek-F2r)1Cgh/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm2Cgh mutation (0 available); any F2rl1 mutation (60 available)
F2rtm1.1Cgh mutation (1 available); any F2r mutation (26 available)
Tg(Tek-F2r)1Cgh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:157446 )
N
• presence of the transgene recues the lethality observed in double null animals; number of embryos observed at 12.5-14.5 days post coitus is equal to number of wild-type embryos collected

nervous system
exencephaly ( J:157446 )
• transgene expression does not prevent exencephaly with about 20% embryos at 12.5-14.5 dpc

cardiovascular system
cardiovascular system phenotype ( J:157446 )
N
• lethality associated with midgestational cardiovascular failure is rescued




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory