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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		F2rl1tm2Cgh
targeted mutation 2, Shaun R Coughlin
MGI:4358416
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		F2rtm2Cgh/F2r+
F2rl1tm2Cgh/F2rl1+ 		involves: 129S4/SvJae * C57BL/6 MGI:4438083
cx2
 		F2rtm1.1Cgh/F2rtm1.1Cgh
F2rl1tm2Cgh/F2rl1tm2Cgh
Tg(Tek-F2r)1Cgh/0 		involves: 129S4/SvJae * C57BL/6 MGI:4438100


Genotype
MGI:4438083
cx1
Allelic
Composition		 F2rtm2Cgh/F2r+
F2rl1tm2Cgh/F2rl1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm2Cgh mutation (0 available); any F2rl1 mutation (60 available)
F2rtm2Cgh mutation (0 available); any F2r mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
incomplete rostral neuropore closure ( J:157446 )
• 22% of embryos from double heterozygous by double null crosses have open hindbrain neuropores at 9.5 days post coitus (dpc)

nervous system
incomplete rostral neuropore closure ( J:157446 )
• 22% of embryos from double heterozygous by double null crosses have open hindbrain neuropores at 9.5 days post coitus (dpc)




Genotype
MGI:4438100
cx2
Allelic
Composition		 F2rtm1.1Cgh/F2rtm1.1Cgh
F2rl1tm2Cgh/F2rl1tm2Cgh
Tg(Tek-F2r)1Cgh/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm2Cgh mutation (0 available); any F2rl1 mutation (60 available)
F2rtm1.1Cgh mutation (1 available); any F2r mutation (26 available)
Tg(Tek-F2r)1Cgh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:157446 )
N
• presence of the transgene recues the lethality observed in double null animals; number of embryos observed at 12.5-14.5 days post coitus is equal to number of wild-type embryos collected

nervous system
exencephaly ( J:157446 )
• transgene expression does not prevent exencephaly with about 20% embryos at 12.5-14.5 dpc

cardiovascular system
cardiovascular system phenotype ( J:157446 )
N
• lethality associated with midgestational cardiovascular failure is rescued




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory