Phenotypes associated with this allele

• Allele Symbol: Tg(Pbsn-Hpn,-GFP)DVv
• Allele Name: transgene insertion D, Valeri Vasioukhin
• Allele ID: MGI:4358581
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Pbsn-Hpn,-GFP)DVv/0 Tg(Pbsn-Tag)12T7fRjm/0	involves: C57BL/6J * CBA * CD-1	MGI:4358595
tg2	Tg(Pbsn-Hpn,-GFP)DVv/0	involves: C57BL/6J * CBA	MGI:4358594

Genotype
MGI:4358595

cx1

• Allelic Composition: Tg(Pbsn-Hpn,-GFP)DVv/0; Tg(Pbsn-Tag)12T7fRjm/0
• Genetic Background: involves: C57BL/6J * CBA * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland adenocarcinoma incidence ( J:92562 )

♂ • at 21 weeks, mice show adenocarcinoma with extensive glandular differentiation and focal areas of cribiform lesions; often neoplastic glands invade the periprostatic stroma

♂ • half of affected male animals, tumor cells show nuclear and chromatin patterns as well ase 'rosette formation' suggestive of neuroendocrine (NE) differentiation

increased prostate intraepithelial neoplasia incidence ( J:92562 )

♂

increased metastatic potential ( J:92562 )

• by 21 weeks of age, 55% of mice develop prominent metastasis with increased levels of transgenic Hpn detected in liver, lung, and bone

• metastases have tightly packed cells displaying nuclear mold and high nuclear/cytoplasmic ratios

reproductive system

abnormal prostate gland morphology ( J:92562 )

♂ • prostate glands display areas with disruption and disorganization of epithelial structures

♂ • cell proliferation is similar to single transgenic Tg(Pbsn-Tag)12T7fRjm mice, but apoptosis is increased by 4-fold

enlarged prostate gland ( J:92562 )

♂ • prostate glands are enlarged, showing similar size and weight to single transgenic mice at 21 weeks

increased prostate gland adenocarcinoma incidence ( J:92562 )

♂ • at 21 weeks, mice show adenocarcinoma with extensive glandular differentiation and focal areas of cribiform lesions; often neoplastic glands invade the periprostatic stroma

♂ • half of affected male animals, tumor cells show nuclear and chromatin patterns as well ase 'rosette formation' suggestive of neuroendocrine (NE) differentiation

increased prostate intraepithelial neoplasia incidence ( J:92562 )

♂

endocrine/exocrine glands

abnormal prostate gland morphology ( J:92562 )

♂ • prostate glands display areas with disruption and disorganization of epithelial structures

♂ • cell proliferation is similar to single transgenic Tg(Pbsn-Tag)12T7fRjm mice, but apoptosis is increased by 4-fold

enlarged prostate gland ( J:92562 )

♂ • prostate glands are enlarged, showing similar size and weight to single transgenic mice at 21 weeks

increased prostate gland adenocarcinoma incidence ( J:92562 )

♂ • at 21 weeks, mice show adenocarcinoma with extensive glandular differentiation and focal areas of cribiform lesions; often neoplastic glands invade the periprostatic stroma

♂ • half of affected male animals, tumor cells show nuclear and chromatin patterns as well ase 'rosette formation' suggestive of neuroendocrine (NE) differentiation

increased prostate intraepithelial neoplasia incidence ( J:92562 )

♂

Genotype
MGI:4358594

tg2

• Allelic Composition: Tg(Pbsn-Hpn,-GFP)DVv/0
• Genetic Background: involves: C57BL/6J * CBA

reproductive system

abnormal prostate gland morphology ( J:92562 )

♂ • 75% of transgenic mice exhibit separation between epithelial and stromal cell layers in contrast to controls

♂ • small areas of separation is observed in 14-week old mice

♂ • ultrastructural analysis of prostatic basement membranes shows microblisters separating the epithelial and stromal cell compartments; disruption is at the level of the basement membrane with compromised adhesion between collagen fibers

endocrine/exocrine glands

abnormal prostate gland morphology ( J:92562 )

♂ • 75% of transgenic mice exhibit separation between epithelial and stromal cell layers in contrast to controls

♂ • small areas of separation is observed in 14-week old mice

♂ • ultrastructural analysis of prostatic basement membranes shows microblisters separating the epithelial and stromal cell compartments; disruption is at the level of the basement membrane with compromised adhesion between collagen fibers