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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apptm1.1Zhe
targeted mutation 1.1, Hui Zheng
MGI:4359011
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1.1Zhe/Apptm1.1Zhe
Chattm2(cre)Lowl/Chat+ 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J MGI:4359069
cn2
 		Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1.1Zhe/Apptm1.1Zhe
Tg(Nes-cre)1Kln/0 		involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL MGI:4359070
cn3
 		Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1.1Zhe/Apptm1.1Zhe
Tg(Ckmm-cre)5Khn/0 		involves: 129S7/SvEvBrd * C57BL/6J * FVB MGI:4359072


Genotype
MGI:4359069
cn1
Allelic
Composition		 Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1.1Zhe/Apptm1.1Zhe
Chattm2(cre)Lowl/Chat+
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2tm1Dbo mutation (1 available); any Aplp2 mutation (32 available)
Apptm1.1Zhe mutation (1 available); any App mutation (105 available)
Chattm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuromuscular synapse morphology ( J:152457 )
• at P0, presynaptic and postsynaptic terminal distribution is diffuse and nerve terminal sprouting occurs unlike in wild-type mice that is not as severe as in Aplp2tm1Dbo Apptm1.2Zhe double homozygotes




Genotype
MGI:4359070
cn2
Allelic
Composition		 Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1.1Zhe/Apptm1.1Zhe
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2tm1Dbo mutation (1 available); any Aplp2 mutation (32 available)
Apptm1.1Zhe mutation (1 available); any App mutation (105 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuromuscular synapse morphology ( J:152457 )
• at E16.5, endplate band width and number are increased compared to in wild-type mice but not as severely as in Aplp2tm1Dbo Apptm1.2Zhe double homozygotes
• at P0, presynaptic and postsynaptic terminal distribution is diffuse and nerve terminal sprouting occurs unlike in wild-type mice that is not as severe as in Aplp2tm1Dbo Apptm1.2Zhe double homozygotes




Genotype
MGI:4359072
cn3
Allelic
Composition		 Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1.1Zhe/Apptm1.1Zhe
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2tm1Dbo mutation (1 available); any Aplp2 mutation (32 available)
Apptm1.1Zhe mutation (1 available); any App mutation (105 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuromuscular synapse morphology ( J:152457 )
• at E16.5, endplate band width and number are increased compared to in wild-type mice that is as severe as in Aplp2tm1Dbo Apptm1.2Zhe double homozygotes
• at P0, presynaptic and postsynaptic terminal distribution is diffuse and nerve terminal sprouting occurs unlike in wild-type that is as severe as in Aplp2tm1Dbo Apptm1.2Zhe double homozygotesmice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory