All Phenotypes App<tm1.2Zhe> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

App^tm1.2Zhe
targeted mutation 1.2, Hui Zheng
MGI:4359012

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.2Zhe/App^tm2.1Zhe	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	MGI:4838052
cx2	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.2Zhe/App^tm1.2Zhe	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4359074

Allelic Composition	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.2Zhe/App^tm2.1Zhe
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2^tm1Dbo mutation (1 available); any Aplp2 mutation (32 available)
App^tm1.2Zhe mutation (0 available); any App mutation (103 available)
App^tm2.1Zhe mutation (0 available); any App mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:165417 )

• most homozygotes die by 21 days of age

• born in normal numbers

Allelic Composition	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.2Zhe/App^tm1.2Zhe
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuromuscular synapse morphology ( J:152457 )

• at E16.5, endplate band width and number are increased compared to in wild-type mice

• at P0, presynaptic and postsynaptic terminal distribution is diffuse and nerve terminal sprouting occurs unlike in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24