Phenotypes associated with this allele

• Allele Symbol: Nmur2^tm1.1Eege
• Allele Name: targeted mutation 1.1, Emil Egecioglu
• Allele ID: MGI:4359163
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nmur2^tm1.1Eege/Nmur2^tm1.1Eege	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4359164

Genotype
MGI:4359164

hm1

• Allelic Composition: Nmur2^tm1.1Eege/Nmur2^tm1.1Eege
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased susceptibility to weight gain ( J:152493 )

• following a 16 hours fast, body weight regain is improved 54% compared to in similarly treated wild-type mice

• however, energy absorption and fecal energy content is normal

increased susceptibility to diet-induced obesity ( J:152493 )

• when fed a high fat diet, female mice exhibit a 10% increase in body weight after 9 weeks unlike similarly treated wild-type mice

adipose tissue

increased total body fat amount ( J:152493 )

• when fed a high fat diet, female mice exhibit a 29% increase in body fat mass unlike wild-type mice

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:152493 )

• when fed a high fat diet, female mice exhibit a 10% increase in body weight after 9 weeks unlike similarly treated wild-type mice

abnormal response/metabolism to endogenous compounds ( J:152493 )

• mice are insensitive to treatment with NMU showing no increase in grooming or paw licking, and female mice fail to exhibit anorexic effects in response to long-term NMU treatment