Phenotypes associated with this allele

• Allele Symbol: Mir145a^tm1Eno
• Allele Name: targeted mutation 1, Eric N Olson
• Allele ID: MGI:4359260
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir145a^tm1Eno/Mir145a^tm1Eno	involves: 129S/SvEv * C57BL/6	MGI:4359267

Genotype
MGI:4359267

hm1

• Allelic Composition: Mir145a^tm1Eno/Mir145a^tm1Eno
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:152458 )

• following carotid artery ligation, 50% of mice die compared to less than 10% of similarly treated wild-type mice

cardiovascular system

abnormal blood vessel morphology ( J:152458 )

• vascular smooth muscle cells exhibit a reduction in the number and prominence of stress fibers compared with wild-type cells

abnormal vascular smooth muscle morphology ( J:152458 )

• vascular smooth muscle cells exhibit a reduction in the number and prominence of stress fibers compared with wild-type cells

vascular smooth muscle hypotrophy ( J:152458 )

• mice exhibit a reduction in vascular smooth muscle wall thickness and in the width of vascular smooth muscle cells in the aorta and other arteries compared with wild-type mice

decreased heart weight ( J:152458 )

• heart weight index and left ventricular index are decreased compared to in wild-type mice

abnormal heart ventricle morphology ( J:152458 )

• ventricular mass is decreased compared to in wild-type mice

decreased mean systemic arterial blood pressure ( J:152458 )

decreased systemic arterial systolic blood pressure ( J:152458 )

abnormal vascular wound healing ( J:152458 )

• following carotid artery ligation, mice fail to exhibit neointimal thickening, exhibit reduced medial layer thickness, and develop neurological abnormalities associated with left hemisphere necrosis prior to death in 50% of mice compared with similarly treated wild-type mice

behavior/neurological

impaired coordination ( J:152458 )

• prior to death induced by carotid artery ligation

circling ( J:152458 )

• prior to death induced by carotid artery ligation

seizures ( J:152458 )

• prior to death induced by carotid artery ligation

homeostasis/metabolism

abnormal vascular wound healing ( J:152458 )

• following carotid artery ligation, mice fail to exhibit neointimal thickening, exhibit reduced medial layer thickness, and develop neurological abnormalities associated with left hemisphere necrosis prior to death in 50% of mice compared with similarly treated wild-type mice

nervous system

seizures ( J:152458 )

• prior to death induced by carotid artery ligation

muscle

abnormal vascular smooth muscle morphology ( J:152458 )

• vascular smooth muscle cells exhibit a reduction in the number and prominence of stress fibers compared with wild-type cells

vascular smooth muscle hypotrophy ( J:152458 )

• mice exhibit a reduction in vascular smooth muscle wall thickness and in the width of vascular smooth muscle cells in the aorta and other arteries compared with wild-type mice