All Phenotypes Nceh1<tm1Ishi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nceh1^tm1Ishi
targeted mutation 1, Shun Ishibashi
MGI:4359388

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nceh1^tm1Ishi/Nceh1^tm1Ishi	B6.129S7-Nceh1^tm1Ishi	MGI:4359426
cx2	Apoe^tm1Unc/Apoe^tm1Unc Nceh1^tm1Ishi/Nceh1^tm1Ishi	B6.129-Nceh1^tm1Ishi Apoe^tm1Unc	MGI:4359427
cx3	Lipe^tm1Ishi/Lipe^tm1Ishi Nceh1^tm1Ishi/Nceh1^tm1Ishi	B6.129S7-Nceh1^tm1Ishi Lipe^tm1Ishi	MGI:4359428
cx4	Ldlr^tm1Her/Ldlr^tm1Her Nceh1^tm1Ishi/Nceh1^tm1Ishi	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4359432
cx5	Ldlr^tm1Her/Ldlr^tm1Her Lipe^tm1Ishi/Lipe^tm1Ishi Nceh1^tm1Ishi/Nceh1^tm1Ishi	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4359435

Allelic Composition	Nceh1^tm1Ishi/Nceh1^tm1Ishi
Genetic Background	B6.129S7-Nceh1^tm1Ishi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nceh1^tm1Ishi mutation (1 available); any Nceh1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased cholesterol efflux ( J:152385 )

• decreased 35% in macrophages in the presence or absence of high-density lipoproteins

abnormal cholesterol homeostasis ( J:152385 )

• following exposure to acLDL, intracellular cholesterol ester levels in macrophages are increased 29% compared to in wild-type mice

• the aortic walls of mice fed a high fat diet exhibit an increase in free cholesterol and cholesterol ester levels compared with similarly treated wild-type mice

immune system

abnormal macrophage physiology ( J:152385 )

• in the presence or absence of high-density lipoproteins, macrophages exhibit a 35% decrease in cholesterol efflux compared with wild-type macrophages

cellular

decreased cholesterol efflux ( J:152385 )

• decreased 35% in macrophages in the presence or absence of high-density lipoproteins

hematopoietic system

abnormal macrophage physiology ( J:152385 )

• in the presence or absence of high-density lipoproteins, macrophages exhibit a 35% decrease in cholesterol efflux compared with wild-type macrophages

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Nceh1^tm1Ishi/Nceh1^tm1Ishi
Genetic Background	B6.129-Nceh1^tm1Ishi Apoe^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (148 available)
Nceh1^tm1Ishi mutation (1 available); any Nceh1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:152385 )

• free cholesterol levels are increased 1.5-fold and 1.3-fold for males and females, respectively, compared to in Apoe^tm1Unc homozygotes

• cholesterol esters are increased 2-fold and 1.3-fold in males and females, respectively, compared to in Apoe^tm1Unc homozygotes

cardiovascular system

increased susceptibility to atherosclerosis ( J:152385 )

• atherosclerotic lesions are increased compared to in Apoe^tm1Unc homozygotes (2.2-fold for males and 2.3-fold in females at 17 weeks, 1.7-fold in males and 2.4-fold for females at 21 weeks)

Allelic Composition	Lipe^tm1Ishi/Lipe^tm1Ishi Nceh1^tm1Ishi/Nceh1^tm1Ishi
Genetic Background	B6.129S7-Nceh1^tm1Ishi Lipe^tm1Ishi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lipe^tm1Ishi mutation (1 available); any Lipe mutation (36 available)
Nceh1^tm1Ishi mutation (1 available); any Nceh1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:152385 )

increased circulating free fatty acids level ( J:152385 )

• in male mice

increased circulating triglyceride level ( J:152385 )

• in male mice

abnormal cholesterol homeostasis ( J:152385 )

• following exposure to acLDL, intracellular cholesterol ester levels in macrophages are increased 70% compared to in wild-type mice

increased circulating cholesterol level ( J:152385 )

Allelic Composition	Ldlr^tm1Her/Ldlr^tm1Her Nceh1^tm1Ishi/Nceh1^tm1Ishi
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (77 available)
Nceh1^tm1Ishi mutation (1 available); any Nceh1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased susceptibility to atherosclerosis ( J:152385 )

• depending on the statistical method, the atherosclerotic lesion surface area is increased 1.6- to 3.1-fold compared to in Ldlr^tm1Her homozygotes

Allelic Composition	Ldlr^tm1Her/Ldlr^tm1Her Lipe^tm1Ishi/Lipe^tm1Ishi Nceh1^tm1Ishi/Nceh1^tm1Ishi
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (77 available)
Lipe^tm1Ishi mutation (1 available); any Lipe mutation (36 available)
Nceh1^tm1Ishi mutation (1 available); any Nceh1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased susceptibility to atherosclerosis ( J:152385 )

• depending on the statistical method, the atherosclerotic lesion surface area is increased 2.0- to 4.3-fold compared to in Ldlr^tm1Her homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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