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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Angptl2tm1Yo
targeted mutation 1, Yuichi Oike
MGI:4359444
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Angptl2tm1Yo/Angptl2tm1Yo B6.Cg-Angptl2tm1Yo MGI:4359628


Genotype
MGI:4359628
hm1
Allelic
Composition
Angptl2tm1Yo/Angptl2tm1Yo
Genetic
Background
B6.Cg-Angptl2tm1Yo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angptl2tm1Yo mutation (0 available); any Angptl2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• subcutaneous body fat is reduced by about a third compared to controls when fed a high fat diet
• mice have lower bodyfat compared to controls when fed a chow diet
• visceral and total body fat is reduced by about a third compared to controls when fed a high fat diet

growth/size/body
• mice weight slightly less than controls when fed a chow diet
• mice weigh 12% less than controls after being fed a high-fat diet for 8 weeks

homeostasis/metabolism
• respiratory quotient is significantly lower than controls when mice are fed a high-fat diet for 8 weeks
• mice show improved glucose tolerance compared to controls when fed a high fat diet
• mice have increased insulin sensitivity compared to controls when fed a high fat diet
• glucose infusion rate and whole-body glucose disposal rates are significantly increased in these mice during hyperinsulinemic-euglycemic clamp experiments

immune system
• less macrophages are recruited to adipose tissues compared to controls in mice fed a high fat diet

integument
• subcutaneous body fat is reduced by about a third compared to controls when fed a high fat diet

cellular
• less macrophages are recruited to adipose tissues compared to controls in mice fed a high fat diet

hematopoietic system
• less macrophages are recruited to adipose tissues compared to controls in mice fed a high fat diet





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory