All Phenotypes Ryr2<tm1.1Wex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ryr2^tm1.1Wex
targeted mutation 1.1, Xander Wehrens
MGI:4359589

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ryr2^tm1.1Wex/Ryr2^tm1.1Wex	B6.129S7-Ryr2^tm1.1Wex	MGI:5571854
hm2	Ryr2^tm1.1Wex/Ryr2^tm1.1Wex	involves: 129S7/SvEvBrd	MGI:4359616

Allelic Composition	Ryr2^tm1.1Wex/Ryr2^tm1.1Wex
Genetic Background	B6.129S7-Ryr2^tm1.1Wex

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2^tm1.1Wex mutation (0 available); any Ryr2 mutation (325 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:179475 )

N	• myocytes exhibit normal calcium spark frequency before and activation of Camk2 • mice exhibit normal cardiac dysfunction in response to transverse aortic constriction

ventricular tachycardia ( J:179475 )

• nonsustained in response to transverse aortic constriction

increased response of heart to induced stress ( J:179475 )

• nonsustained ventricular tachycardia in response to transverse aortic constriction

• however, mice exhibit normal cardiac dysfunction in response to transverse aortic constriction

homeostasis/metabolism