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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pou3f2tm1Mejr
targeted mutation 1, Dies Meijer
MGI:4359591
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pou3f2tm1Mejr/Pou3f2tm1Mejr
Tg(Dhh-cre)1Mejr/0 		involves: 129P2/OlaHsd * FVB/N MGI:4359759
cn2
 		Pou3f1tm1Mejr/Pou3f1tm2.1Mejr
Pou3f2tm1Mejr/Pou3f2tm1Mejr
Tg(Dhh-cre)1Mejr/0 		involves: 129P2/OlaHsd * FVB/N MGI:4359761


Genotype
MGI:4359759
cn1
Allelic
Composition		 Pou3f2tm1Mejr/Pou3f2tm1Mejr
Tg(Dhh-cre)1Mejr/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou3f2tm1Mejr mutation (0 available); any Pou3f2 mutation (19 available)
Tg(Dhh-cre)1Mejr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:83739 )
N
• animals are normal and healthy; sciatic nerves of P8 mice show no obvious morphological abnormalities




Genotype
MGI:4359761
cn2
Allelic
Composition		 Pou3f1tm1Mejr/Pou3f1tm2.1Mejr
Pou3f2tm1Mejr/Pou3f2tm1Mejr
Tg(Dhh-cre)1Mejr/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou3f1tm1Mejr mutation (0 available); any Pou3f1 mutation (14 available)
Pou3f1tm2.1Mejr mutation (0 available); any Pou3f1 mutation (14 available)
Pou3f2tm1Mejr mutation (0 available); any Pou3f2 mutation (19 available)
Tg(Dhh-cre)1Mejr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:83739 )
• at P56 and P120 (about 55% and 25%), respectively, of nerves are abnormal with many promyelin configurations
abnormal myelination ( J:83739 )
• at P16 nerves contain many promyelin configurations in contrast to wild type and heterozygotes in which >90% of large-caliber axons are myelinated
• at P56 and P120, abnormal axons are thinly myelinated resembling wild-type nerves during the first postnatal week




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory