Phenotypes associated with this allele

• Allele Symbol: Themis^Spotr
• Allele Name: single positive thymoycte reduction
• Allele ID: MGI:4359649
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Themis^Spotr/Themis^Spotr	C57BL/6-Themis^Spotr	MGI:4359658
ht2	Themis^Spotr/Themis^+	C57BL/6-Themis^Spotr	MGI:4359659

Genotype
MGI:4359658

hm1

• Allelic Composition: Themis^Spotr/Themis^Spotr
• Genetic Background: C57BL/6-Themis^Spotr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

small thymus medulla ( J:152601 )

• thymus medulla is smaller while the cortex is unaffected

abnormal T cell differentiation ( J:152601 )

• T cell development is partially arrested between the double-positive and single-positive stages

• heat stable antigen and CD69 expression levels suggest defects in positive selection of the single-positive thymocytes

• bone marrow chimera experiments demonstrate defects are intrinsic to hematopoietic cells

decreased CD4-positive, alpha-beta T cell number ( J:152601 )

• CD4⁺ T cell numbers are reduced 10-fold in the periphery

• CD4-single positive thymocyte numbers are reduced by about 60%

decreased CD8-positive, alpha-beta T cell number ( J:152601 )

• CD8⁺ T cell numbers are reduced 3-fold in the periphery

• CD8-single positive thymocyte numbers are reduced by 40%

hematopoietic system

small thymus medulla ( J:152601 )

• thymus medulla is smaller while the cortex is unaffected

abnormal T cell differentiation ( J:152601 )

• T cell development is partially arrested between the double-positive and single-positive stages

• heat stable antigen and CD69 expression levels suggest defects in positive selection of the single-positive thymocytes

• bone marrow chimera experiments demonstrate defects are intrinsic to hematopoietic cells

decreased CD4-positive, alpha-beta T cell number ( J:152601 )

• CD4⁺ T cell numbers are reduced 10-fold in the periphery

• CD4-single positive thymocyte numbers are reduced by about 60%

decreased CD8-positive, alpha-beta T cell number ( J:152601 )

• CD8⁺ T cell numbers are reduced 3-fold in the periphery

• CD8-single positive thymocyte numbers are reduced by 40%

endocrine/exocrine glands

small thymus medulla ( J:152601 )

• thymus medulla is smaller while the cortex is unaffected

Genotype
MGI:4359659

ht2

• Allelic Composition: Themis^Spotr/Themis⁺
• Genetic Background: C57BL/6-Themis^Spotr

immune system

decreased CD4-positive, alpha-beta T cell number ( J:152601 )

• CD4⁺ T cell numbers are significantly reduced in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:152601 )

• CD8⁺ T cell numbers are significantly reduced in the periphery

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:152601 )

• CD4⁺ T cell numbers are significantly reduced in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:152601 )

• CD8⁺ T cell numbers are significantly reduced in the periphery