All Phenotypes Themis<tm1.1Hko> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Themis^tm1.1Hko
targeted mutation 1.1, Haruhiko Koseki
MGI:4359650

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Themis^tm1.1Hko/Themis^tm1.1Hko	Not Specified	MGI:4359660
ht2	Themis^tm1.1Hko/Themis⁺	Not Specified	MGI:4359661

Allelic Composition	Themis^tm1.1Hko/Themis^tm1.1Hko
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themis^tm1.1Hko mutation (0 available); any Themis mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:152601 )

• CD4⁺ T cell numbers are reduced 10-fold in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:152601 )

• CD8⁺ T cell numbers are reduced 5-fold in the periphery

decreased single-positive T cell number ( J:152601 )

• single positive thymocyte numbers are dramatically reduced in these mice

• CD4-single positive numbers are reduced by about 60% and CD8-single positive numbers by 40%

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:152601 )

• CD4⁺ T cell numbers are reduced 10-fold in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:152601 )

• CD8⁺ T cell numbers are reduced 5-fold in the periphery

decreased single-positive T cell number ( J:152601 )

• single positive thymocyte numbers are dramatically reduced in these mice

• CD4-single positive numbers are reduced by about 60% and CD8-single positive numbers by 40%

Allelic Composition	Themis^tm1.1Hko/Themis⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themis^tm1.1Hko mutation (0 available); any Themis mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:152601 )

• CD4⁺ T cell numbers are reduced in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:152601 )

• CD8⁺ T cell numbers are reduced in the periphery

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:152601 )

• CD4⁺ T cell numbers are reduced in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:152601 )

• CD8⁺ T cell numbers are reduced in the periphery

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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