Analysis Tools
reproductive system
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• pregranulosa cells appear to undergo precocious differentiation from quiescence to differentiating cell, based on aberrant expression of markers of ovarian development at 18.5 dpc
• in null ovaries, pregranulosa cells in the agametic anterior end resemble differentiating granulosa cells while the cells adjacent to surviving germ cells at the posterior end of the ovary are undifferentiated
• when embryos are exposed to bisulfan at E11.5 and all germ cells are ablated, mitotic arrest of granulosa cells occurs as in controls, with no aberrant differentiation of pregranulosa cells; in absence of pre-meiotic germ cells pregranulosa cells remain in normal quiescent state
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• loss of germ cells in the ovary proceeds from the anterior to posterior end; At 15.5 dpc, germ cells at the anterior end are reduced in number compared to control ovaries
• germ cells occupy half the ovary by 16.5 dpc and only a small number of germ cells remain, clustered at the posterior end of the ovary
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cellular
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• pregranulosa cells appear to undergo precocious differentiation from quiescence to differentiating cell, based on aberrant expression of markers of ovarian development at 18.5 dpc
• in null ovaries, pregranulosa cells in the agametic anterior end resemble differentiating granulosa cells while the cells adjacent to surviving germ cells at the posterior end of the ovary are undifferentiated
• when embryos are exposed to bisulfan at E11.5 and all germ cells are ablated, mitotic arrest of granulosa cells occurs as in controls, with no aberrant differentiation of pregranulosa cells; in absence of pre-meiotic germ cells pregranulosa cells remain in normal quiescent state
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• loss of germ cells in the ovary proceeds from the anterior to posterior end; At 15.5 dpc, germ cells at the anterior end are reduced in number compared to control ovaries
• germ cells occupy half the ovary by 16.5 dpc and only a small number of germ cells remain, clustered at the posterior end of the ovary
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