About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grk5tm2Rjl
targeted mutation 2, Robert J Lefkowitz
MGI:4359730
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Grk5tm2Rjl/Grk5+ B6.129S4-Grk5tm2Rjl MGI:4359758
cn2
 		Grk5tm2Rjl/Grk5tm2Rjl
Tg(Myh6-cre)2182Mds/0 		involves: 129S4/SvJaeSor * C57BL/6J * FVB/N MGI:5582621


Genotype
MGI:4359758
ht1
Allelic
Composition		 Grk5tm2Rjl/Grk5+
Genetic
Background		 B6.129S4-Grk5tm2Rjl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grk5tm2Rjl mutation (1 available); any Grk5 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:152746 )
• mice are viable and fertile and show no obvious abnormal phenotype




Genotype
MGI:5582621
cn2
Allelic
Composition		 Grk5tm2Rjl/Grk5tm2Rjl
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grk5tm2Rjl mutation (1 available); any Grk5 mutation (44 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac hypertrophy ( J:212635 )
• 12 weeks after transaortic constriction, mice exhibit attenuated cardiac hypertrophy compared with wild-type mice
decreased response of heart to induced stress ( J:212635 )
• 12 weeks after transaortic constriction, mice exhibit attenuated cardiac hypertrophy with no increase in left ventricular dilatation and no change in ejection fraction compared with wild-type mice

homeostasis/metabolism
decreased response of heart to induced stress ( J:212635 )
• 12 weeks after transaortic constriction, mice exhibit attenuated cardiac hypertrophy with no increase in left ventricular dilatation and no change in ejection fraction compared with wild-type mice

growth/size/body
cardiac hypertrophy ( J:212635 )
• 12 weeks after transaortic constriction, mice exhibit attenuated cardiac hypertrophy compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory