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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Lmx1a-cre)1Kjmi
transgene insertion 1, Kathleen J Millen
MGI:4359769
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lmx1adr-J/Lmx1adr-J
Lmx1btm1Rjo/Lmx1btm1Zfc
Tg(Lmx1a-cre)1Kjmi/0 		involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6 MGI:4359810
cn2
 		Lmx1btm1Rjo/Lmx1btm1Zfc
Tg(Lmx1a-cre)1Kjmi/0 		involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6 MGI:4359811


Genotype
MGI:4359810
cn1
Allelic
Composition		 Lmx1adr-J/Lmx1adr-J
Lmx1btm1Rjo/Lmx1btm1Zfc
Tg(Lmx1a-cre)1Kjmi/0
Genetic
Background		 involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1adr-J mutation (1 available); any Lmx1a mutation (21 available)
Lmx1btm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
Lmx1btm1Zfc mutation (0 available); any Lmx1b mutation (16 available)
Tg(Lmx1a-cre)1Kjmi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal fourth ventricle morphology ( J:152673 )
• fourth ventricle roof plate size is dramatically smaller relative to wild-type or Lmx1a-null mice at E10.5
abnormal cerebellum morphology ( J:152673 )
• P20 mice show severe cerebellar defects
abnormal cerebellum development ( J:152673 )
• at E12.5, reduced proliferation is observed in the cerebellar anlage
small cerebellum ( J:152673 )
• cerebellum is reduced in size




Genotype
MGI:4359811
cn2
Allelic
Composition		 Lmx1btm1Rjo/Lmx1btm1Zfc
Tg(Lmx1a-cre)1Kjmi/0
Genetic
Background		 involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1btm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
Lmx1btm1Zfc mutation (0 available); any Lmx1b mutation (16 available)
Tg(Lmx1a-cre)1Kjmi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:152673 )
N
• rhombomere 1 roofplate is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory