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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc30a8tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:4359863
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc30a8tm1Lex/Slc30a8tm1Lex involves: 129S6/SvEvTac * C57BL/6 MGI:4359886


Genotype
MGI:4359886
hm1
Allelic
Composition
Slc30a8tm1Lex/Slc30a8tm1Lex
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc30a8tm1Lex mutation (1 available); any Slc30a8 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• despite reduction in serum insulin levels, mice exhibit normal whole-body glucose metabolism
• glucose-stimulated insulin secretion is reduced 33% compared to in similarly treated wild-type cells
• zinc content in islets is reduced compared to in wild-type cells

endocrine/exocrine glands
• glucose-stimulated insulin secretion is reduced 33% compared to in similarly treated wild-type cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory