Phenotypes associated with this allele

• Allele Symbol: Ghr^tm1.1Masp
• Allele Name: targeted mutation 1.1, Mark A Sperling
• Allele ID: MGI:4359891
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ghr^tm1.1Masp/Ghr^tm1.1Masp Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S4/SvJaeSor * C57BL/6 * DBA	MGI:4359908

Genotype
MGI:4359908

cn1

• Allelic Composition: Ghr^tm1.1Masp/Ghr^tm1.1Masp; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decreased bone density in Ghr^tm1.1Masp/Ghr^tm1.1Masp Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice

homeostasis/metabolism

increased circulating insulin level ( J:152627 )

• 2 to 3 times

decreased circulating insulin-like growth factor I level ( J:152627 )

• 95%

increased circulating growth hormone level ( J:152627 )

• 4-fold

increased circulating free fatty acids level ( J:152627 )

• 30%

decreased circulating triglyceride level ( J:152627 )

impaired glucose tolerance ( J:152627 )

decreased liver triglyceride level ( J:152627 )

• triglyceride secretion from the liver is impaired compared to in wild-type mice

liver/biliary system

increased liver weight ( J:152627 )

decreased liver triglyceride level ( J:152627 )

• triglyceride secretion from the liver is impaired compared to in wild-type mice

hepatic steatosis ( J:152627 )

renal/urinary system

decreased kidney weight ( J:152627 )

skeleton

decreased bone mineral density ( J:152627 )

growth/size/body

increased liver weight ( J:152627 )