About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srrttm1.2Thsn
targeted mutation 1.2, Craig B Thompson
MGI:4360112
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Srrttm1.1Thsn/Srrttm1.2Thsn
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:4360118


Genotype
MGI:4360118
cn1
Allelic
Composition		 Srrttm1.1Thsn/Srrttm1.2Thsn
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srrttm1.1Thsn mutation (0 available); any Srrt mutation (55 available)
Srrttm1.2Thsn mutation (0 available); any Srrt mutation (55 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased splenocyte apoptosis ( J:152729 )
• in pIpC-treated mice
abnormal thymus physiology ( J:152729 )
• pIpC-treated mice exhibit increased thymic apoptosis compared with Srrttm1.1Thsn/Srrttm1.2Thsn control mice
decreased bone marrow cell number ( J:152729 )
• in pIpC-treated mice

immune system
increased splenocyte apoptosis ( J:152729 )
• in pIpC-treated mice
abnormal thymus physiology ( J:152729 )
• pIpC-treated mice exhibit increased thymic apoptosis compared with Srrttm1.1Thsn/Srrttm1.2Thsn control mice

cellular
increased splenocyte apoptosis ( J:152729 )
• in pIpC-treated mice

endocrine/exocrine glands
abnormal thymus physiology ( J:152729 )
• pIpC-treated mice exhibit increased thymic apoptosis compared with Srrttm1.1Thsn/Srrttm1.2Thsn control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory