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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Inpp5etm1.1Ssch
targeted mutation 1.1, Stephane Schurmans
MGI:4360186
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Inpp5etm1.1Ssch/Inpp5etm1.2Ssch
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4360189


Genotype
MGI:4360189
cn1
Allelic
Composition		 Inpp5etm1.1Ssch/Inpp5etm1.2Ssch
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5etm1.1Ssch mutation (0 available); any Inpp5e mutation (29 available)
Inpp5etm1.2Ssch mutation (0 available); any Inpp5e mutation (29 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:152712 )
• mice display increased body weight after tamoxifen treatment
kidney cortex cyst ( J:152712 )
• glomerular cysts are seen in 6 month old tamoxifen treated mice

renal/urinary system
kidney cortex cyst ( J:152712 )
• glomerular cysts are seen in 6 month old tamoxifen treated mice

vision/eye
abnormal retina photoreceptor layer morphology ( J:152712 )
• after tamoxifen treatment the retinal photoreceptor layer is completely absent




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory