Analysis Tools
nervous system
 N |
• mice exhibit normal presynaptic plasticity during tetanus, magnitude of long term potentiation, cumulative probability distribution, and contextual conditioning
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Allele Symbol Allele Name Allele ID |
Tg(Camk2a-HRAS*G12V)1Sva transgene insertion 1, Alcino Silva MGI:4360216 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• mice exhibit normal presynaptic plasticity during tetanus, magnitude of long term potentiation, cumulative probability distribution, and contextual conditioning
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal dendritic spine density, active zone area, axon terminal volume, postsynaptic density thickness, and synapse density
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• more vesicles are docked at synapses than in wild-type mice
• however, the total number of vesicles is normal
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• following theta burst stimulation, mice exhibit increased short term potentiation compared with similarly treated wild-type mice
• high frequency theta burst stimulation produces an greater increase in short term potentiation compared to in similarly treated wild-type mice
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• at the end of tetanus, field excitatory postsynaptic potential (fEPSP) slope is larger than in wild-type mice and Syn1tm1Sud/Syn1tm1Sud Tg(Camk2a-HRAS1*G12V)1Sva mice
• fEPSP amplitude is increased in response to each theta burst compared with wild-type mice
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• following theta burst stimulation, mice exhibit increased long term potentiation compared with similarly treated wild-type mice with a cumulative probability distribution shift towards larger potentiation
• high frequency theta burst stimulation produces an greater increase in long term potentiation compared to in similarly treated wild-type mice
• however, pairing-induced associative long term potentiation is normal
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• mice exhibit increased in frequency, but not amplitude, of miniature excitatory postsynaptic currents (mEPSCs) compared with wild-type mice
• however, treatment with the MEK inhibitor U0126 abolishes increased mEPSC frequency
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• mice exhibit frequency-dependent enhancement of paired-pulse facilitation compared with wild-type mice
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| N |
• mice exhibit normal long-term stability of spatial memory
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• mice exhibit enhanced hippocampus-dependent contextual learning compared with wild-type mice
• mice exhibit increased freezing at 2 and 24 hours after training compared with wild-type mice indicating enhanced short-term memory
• after immediate shck treatment, preexposure mice exhibit enhanced freezing unlike in similarly treated wild-type mic
• however, mice that are not preexposed exhibit normal freezing following immediate shock training
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• in a Morris water maze, mice require less training time to learn a spatial location compared with wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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