hematopoietic system
• the transgene partially rescues arrest of T cell development associated with Lck deficiency
• thymocyte numbers are normal
• splenic gamma-delta T cell numbers are normal
• expression of TCR and CD5 on transitional single-positive thymocytes is slightly lower than controls
|
• alpha beta T cell numbers are less than half of wild-type controls
|
immune system
• the transgene partially rescues arrest of T cell development associated with Lck deficiency
• thymocyte numbers are normal
• splenic gamma-delta T cell numbers are normal
• expression of TCR and CD5 on transitional single-positive thymocytes is slightly lower than controls
|
• alpha beta T cell numbers are less than half of wild-type controls
|