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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Lck-Fyn*Y528F)5525Cjg
transgene insertion 5525, Cynthia J Guidos
MGI:4360310
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Lcktm1Mak/Lcktm1Mak
Rag1tm1Mom/Rag1+
Tg(Lck-Fyn*Y528F)5525Cjg/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:4360345


Genotype
MGI:4360345
cx1
Allelic
Composition
Lcktm1Mak/Lcktm1Mak
Rag1tm1Mom/Rag1+
Tg(Lck-Fyn*Y528F)5525Cjg/0
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcktm1Mak mutation (1 available); any Lck mutation (95 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(Lck-Fyn*Y528F)5525Cjg mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• the transgene partially rescues arrest of T cell development associated with Lck deficiency
• thymocyte numbers are normal
• splenic gamma-delta T cell numbers are normal
• expression of TCR and CD5 on transitional single-positive thymocytes is slightly lower than controls
• alpha beta T cell numbers are less than half of wild-type controls

immune system
• the transgene partially rescues arrest of T cell development associated with Lck deficiency
• thymocyte numbers are normal
• splenic gamma-delta T cell numbers are normal
• expression of TCR and CD5 on transitional single-positive thymocytes is slightly lower than controls
• alpha beta T cell numbers are less than half of wild-type controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory