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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pak4tm2.2Amin
targeted mutation 2.2, Audrey Minden
MGI:4360338
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Meox2tm1(cre)Sor/Meox2+
Pak4tm2.1Amin/Pak4tm2.2Amin 		involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:4360348
cn2
 		Pak4tm2.1Amin/Pak4tm2.2Amin
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N MGI:4360349


Genotype
MGI:4360348
cn1
Allelic
Composition		 Meox2tm1(cre)Sor/Meox2+
Pak4tm2.1Amin/Pak4tm2.2Amin
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Pak4tm2.1Amin mutation (1 available); any Pak4 mutation (94 available)
Pak4tm2.2Amin mutation (0 available); any Pak4 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal placenta labyrinth morphology ( J:152821 )
• authors state that mice exhibit the same defects as observed in Pak4tm2.1Amin/Pak4tm2.2Amin Tg(Sox2-cre)1Amc mice
abnormal visceral yolk sac morphology ( J:152821 )
• authors state that mice exhibit the same defects as observed in Pak4tm2.1Amin/Pak4tm2.2Amin Tg(Sox2-cre)1Amc mice




Genotype
MGI:4360349
cn2
Allelic
Composition		 Pak4tm2.1Amin/Pak4tm2.2Amin
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Pak4tm2.1Amin mutation (1 available); any Pak4 mutation (94 available)
Pak4tm2.2Amin mutation (0 available); any Pak4 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:152821 )
• no mice are recovered (no time point given)

embryo
abnormal placenta labyrinth morphology ( J:152821 )
• authors state that mice resemble Pak4tm1Amin
abnormal visceral yolk sac morphology ( J:152821 )
• authors state that mice resemble Pak4tm1Amin

growth/size/body
embryonic growth retardation ( J:152821 )




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory