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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Erbb3tm2.1Dwt
targeted mutation 2.1, David Threadgill
MGI:4360355
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Erbb3tm1.1Dwt/Erbb3tm2.1Dwt involves: 129S6/SvEvTac * C57BL/6 MGI:4360360
cn2
 		ApcMin/Apc+
Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
Tg(Vil1-cre)997Gum/0 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL MGI:4360363
cn3
 		Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:4360361
cn4
 		Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
Tg(Vil1-cre)997Gum/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:4360362


Genotype
MGI:4360360
ht1
Allelic
Composition		 Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3tm1.1Dwt mutation (1 available); any Erbb3 mutation (48 available)
Erbb3tm2.1Dwt mutation (0 available); any Erbb3 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:152703 )
• mice are normal and fertile




Genotype
MGI:4360363
cn2
Allelic
Composition		 ApcMin/Apc+
Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Erbb3tm1.1Dwt mutation (1 available); any Erbb3 mutation (48 available)
Erbb3tm2.1Dwt mutation (0 available); any Erbb3 mutation (48 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:152703 )
N
• unlike ApcMin heterozygotes, mice do not develop colonic polyps
intestine polyps ( J:152703 )
• mice develop fewer intestinal polyps compared to in ApcMin heterozygotes

neoplasm
decreased tumor incidence ( J:152703 )
• the number and size of microadenomas in the intestine are decreased compared to in ApcMin heterozygotes due to an increased in Caspase-3 dependent apoptosis
• mice fail to develop colon tumors unlike ApcMin heterozygotes




Genotype
MGI:4360361
cn3
Allelic
Composition		 Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Erbb3tm1.1Dwt mutation (1 available); any Erbb3 mutation (48 available)
Erbb3tm2.1Dwt mutation (0 available); any Erbb3 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:152703 )
• no mice were detected (no time of death given)




Genotype
MGI:4360362
cn4
Allelic
Composition		 Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3tm1.1Dwt mutation (1 available); any Erbb3 mutation (48 available)
Erbb3tm2.1Dwt mutation (0 available); any Erbb3 mutation (48 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased susceptibility to induced colitis ( J:152703 )
• following treatment with DSS, mice exhibit greater weight loss than similarly treated control mice and mild lesions with loss of mucus cells, glandular hyperplasia, and increased leukocyte levels in the lamina propria to severe lesions with complete loss of glandular epithelium, followed by collapse of denuded lamina propria, submucosal edema, fibrinoid necrosis of lamina propria vessels, and infiltration of neutrophils and plasma cells

immune system
increased susceptibility to induced colitis ( J:152703 )
• following treatment with DSS, mice exhibit greater weight loss than similarly treated control mice and mild lesions with loss of mucus cells, glandular hyperplasia, and increased leukocyte levels in the lamina propria to severe lesions with complete loss of glandular epithelium, followed by collapse of denuded lamina propria, submucosal edema, fibrinoid necrosis of lamina propria vessels, and infiltration of neutrophils and plasma cells




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory