Phenotypes associated with this allele

• Allele Symbol: Prom1^{tm1.1(DTA)Toko}
• Allele Name: targeted mutation 1.1, Toru Kondo
• Allele ID: MGI:4360366
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prom1^tm1.1(DTA)Toko/Prom1^tm1.1(DTA)Toko	B6.Cg-Prom1^tm1.1(DTA)Toko/Rbrc	MGI:6384246
hm2	Prom1^tm1.1(DTA)Toko/Prom1^tm1.1(DTA)Toko	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:6384247
hm3	Prom1^tm1.1(DTA)Toko/Prom1^tm1.1(DTA)Toko	involves: C57BL/6 * SJL	MGI:4360391
cn4	Prom1^tm1.1(DTA)Toko/Prom1^tm1.1(DTA)Toko Tg(CAG-cre/Esr1*)5Amc/0	involves: C57BL/6 * CBA * SJL	MGI:4360394

Genotype
MGI:6384246

hm1

• Allelic Composition: Prom1^{tm1.1(DTA)Toko}/Prom1^{tm1.1(DTA)Toko}
• Genetic Background: B6.Cg-Prom1^{tm1.1(DTA)Toko}/Rbrc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

decreased retina photoreceptor cell number ( J:230988 )

• at P30

• however, mice raised in complete darkness exhibit photoreceptor retention

retina photoreceptor degeneration ( J:230988 )

• Background Sensitivity: at P20, mice on a congenic C57BL/6 background exhibit loss of the photoreceptor cell layer including the outer segment with missing cell body that is more severe than in mice on a mixed background

• however, retinal structure at P14 is normal

thin retina inner nuclear layer ( J:230988 )

• Background Sensitivity: unlike in mice on a mixed background

thin retina inner plexiform layer ( J:230988 )

• Background Sensitivity: at P20 unlike in mice on a mixed background

thin retina outer nuclear layer ( J:230988 )

• Background Sensitivity: more severe than in mice on mixed background

thin retina outer plexiform layer ( J:230988 )

• Background Sensitivity: more severe than in mice on mixed background

nervous system

decreased retina photoreceptor cell number ( J:230988 )

• at P30

• however, mice raised in complete darkness exhibit photoreceptor retention

retina photoreceptor degeneration ( J:230988 )

• Background Sensitivity: at P20, mice on a congenic C57BL/6 background exhibit loss of the photoreceptor cell layer including the outer segment with missing cell body that is more severe than in mice on a mixed background

• however, retinal structure at P14 is normal

Genotype
MGI:6384247

hm2

• Allelic Composition: Prom1^{tm1.1(DTA)Toko}/Prom1^{tm1.1(DTA)Toko}
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

vision/eye

decreased retina photoreceptor cell number ( J:230988 )

• at P30

• however, mice raised in complete darkness or treated with fenretinide exhibit photoreceptor retention

photoreceptor inner segment degeneration ( J:230988 )

• layer is absent by 4 months

decreased photoreceptor outer segment number ( J:230988 )

• extensive after P14

short photoreceptor outer segment ( J:230988 )

• at P20

disorganized photoreceptor outer segment ( J:230988 )

• disorganized and misaligned at P20

photoreceptor outer segment degeneration ( J:230988 )

• layer is absent by 4 months

retina photoreceptor degeneration ( J:230988 )

• Background Sensitivity: mice on a mixed background exhibit less extensive loss of the outer plexiform layer, the outer nuclear layer and outer segment to inner segment compared with mice on a congenic C57BL/6 background

• however, the inner nuclear layer and inner plexiform layer are largely unaffected

thin retina outer nuclear layer ( J:230988 )

• Background Sensitivity: not as severe as in mice on a congenic C57BL/6 background at P20

retina outer nuclear layer degeneration ( J:230988 )

• layer is absent by 4 months

thin retina outer plexiform layer ( J:230988 )

• Background Sensitivity: not as severe as in mice on a congenic C57BL/6 background at P20

abnormal cone electrophysiology ( J:230988 )

• reduced a- and b-wave amplitudes

• however, mice raised in complete darkness exhibit rescued function

abnormal rod electrophysiology ( J:230988 )

• reduced a- and b-wave amplitudes

• however, mice raised in complete darkness or treated with fenretinide exhibit rescued function

nervous system

decreased retina photoreceptor cell number ( J:230988 )

• at P30

• however, mice raised in complete darkness or treated with fenretinide exhibit photoreceptor retention

photoreceptor inner segment degeneration ( J:230988 )

• layer is absent by 4 months

decreased photoreceptor outer segment number ( J:230988 )

• extensive after P14

short photoreceptor outer segment ( J:230988 )

• at P20

disorganized photoreceptor outer segment ( J:230988 )

• disorganized and misaligned at P20

photoreceptor outer segment degeneration ( J:230988 )

• layer is absent by 4 months

retina photoreceptor degeneration ( J:230988 )

• Background Sensitivity: mice on a mixed background exhibit less extensive loss of the outer plexiform layer, the outer nuclear layer and outer segment to inner segment compared with mice on a congenic C57BL/6 background

• however, the inner nuclear layer and inner plexiform layer are largely unaffected

Genotype
MGI:4360391

hm3

• Allelic Composition: Prom1^{tm1.1(DTA)Toko}/Prom1^{tm1.1(DTA)Toko}
• Genetic Background: involves: C57BL/6 * SJL

normal phenotype

no abnormal phenotype detected ( J:152390 )

• mice are viable and develop normally

Genotype
MGI:4360394

cn4

• Allelic Composition: Prom1^{tm1.1(DTA)Toko}/Prom1^{tm1.1(DTA)Toko}; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: C57BL/6 * CBA * SJL

nervous system

increased brain apoptosis ( J:152390 )

• tamoxifen treated mice exhibit increased apoptosis in the granular layer of the cerebellum, cortex of telencephalon, white matter and midbrain unlike similarly treated and untreated control mice

• however, ventricular zone cells and their neurogenesis are normal in tamoxifen treated mice

growth/size/body

decreased body weight ( J:152390 )

• tamoxifen treated mice exhibit reduced body weight compared with untreated and treated control mice

behavior/neurological

ataxia ( J:152390 )

• tamoxifen treated mice exhibit walking abnormalities

cellular

increased brain apoptosis ( J:152390 )

• tamoxifen treated mice exhibit increased apoptosis in the granular layer of the cerebellum, cortex of telencephalon, white matter and midbrain unlike similarly treated and untreated control mice

• however, ventricular zone cells and their neurogenesis are normal in tamoxifen treated mice