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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Drd1-tdTomato)5Calak
transgene insertion 5, Nicole Calakos
MGI:4360387
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Nlgn3tm2.1Sud/Y
Tg(Drd1-tdTomato)5Calak/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5660858
cx2
 		Nlgn3tm1Sud/Y
Tg(Drd1-tdTomato)5Calak/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5660860


Genotype
MGI:5660858
cx1
Allelic
Composition		 Nlgn3tm2.1Sud/Y
Tg(Drd1-tdTomato)5Calak/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm2.1Sud mutation (1 available); any Nlgn3 mutation (36 available)
Tg(Drd1-tdTomato)5Calak mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased miniature inhibitory postsynaptic current frequency ( J:214636 )
• mice show a reduction of synaptic inhibition onto D1-dopamine receptor-expressing medium spiny neurons of the nucleus accumbens, with the miniature inhibitory postsynaptic current (mIPSC) frequency in the nucleus accumbens reduced by about 50%, whereas the mIPSC amplitude is unchanged
• however, no change in mIPSC frequency or amplitude is seen in D2-dopamine receptor-expressing medium spiny neurons and no change is seen in mIPSC frequency or amplitude in D1-dopamine receptor-expressing medium spiny neurons of the dorsal striatum
• spontaneous miniature excitatory postsynaptic currents (mEPSCs) from medium spiny neurons are normal, no changes in paired-pulse ratio of evoked EPSCs, and function of group I metabotropic glutamate receptors in medium spiny neurons of the nucleus acumbens is not altered




Genotype
MGI:5660860
cx2
Allelic
Composition		 Nlgn3tm1Sud/Y
Tg(Drd1-tdTomato)5Calak/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm1Sud mutation (1 available); any Nlgn3 mutation (36 available)
Tg(Drd1-tdTomato)5Calak mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased miniature inhibitory postsynaptic current frequency ( J:214636 )
• mice show a reduction of synaptic inhibition onto D1-dopamine receptor-expressing medium spiny neurons of the nucleus accumbens, with the miniature inhibitory postsynaptic current (mIPSC) frequency in the nucleus accumbens reduced by about 50%, whereas the mIPSC amplitude is unchanged
• however, no change in mIPSC frequency or amplitude is seen in D2-dopamine receptor-expressing medium spiny neurons and no change is seen in mIPSC frequency or amplitude in D1-dopamine receptor-expressing medium spiny neurons of the dorsal striatum




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory