Phenotypes associated with this allele

• Allele Symbol: Ankrd17^tm1.1Yty
• Allele Name: targeted mutation 1.1, Yu-Ting Yan
• Allele ID: MGI:4360512
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ankrd17^tm1.1Yty/Ankrd17^tm1.1Yty	B6.129P2-Ankrd17^tm1.1Yty	MGI:4360513

Genotype
MGI:4360513

hm1

• Allelic Composition: Ankrd17^tm1.1Yty/Ankrd17^tm1.1Yty
• Genetic Background: B6.129P2-Ankrd17^tm1.1Yty

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:152840 )

• die around E11.5

cardiovascular system

abnormal blood vessel morphology ( J:152840 )

• at E10.5, the diameter of the blood vessels is less regular

abnormal capillary morphology ( J:152840 )

• at E10.5, the capillary network of the somites is less organized than in controls

abnormal vascular development ( J:152840 )

• at E10.5, expression analysis suggests that migration of induced vascular smooth muscle cell precursors from originating sites to the immature vessels is impaired

abnormal vascular smooth muscle morphology ( J:152840 )

• at E10.5, expression analysis suggests a decrease in the vascular smooth muscle cells surrounding the blood vessels

• at E10.5 the expression pattern of smooth muscle alpha actin is diffused and mislocalized

trabecula carnea hypoplasia ( J:152840 )

• seen at E10.5

thin myocardium ( J:152840 )

• seen at E10.5

abnormal cardiac mesenchyme morphology ( J:152840 )

• at E10.5, the mesenchymal compartment is less condensed

abnormal heart development ( J:152840 )

• at E10.5 arrest of endocardium development is seen

distended pericardium ( J:152840 )

internal hemorrhage ( J:152840 )

• hemorrhages are seen in the ventral parts of the trunk

hemopericardium ( J:152840 )

intracranial hemorrhage ( J:152840 )

• hemorrhages are seen in the brain region

increased vascular permeability ( J:152840 )

• at E10.5 India ink injected into the heart leaks out of the blood vessels indicating impaired vessel integrity

embryo

embryonic growth retardation ( J:152840 )

abnormal neural tube morphology ( J:152840 )

• thinner at E10.5

pale yolk sac ( J:152840 )

nervous system

intracranial hemorrhage ( J:152840 )

• hemorrhages are seen in the brain region

abnormal neural tube morphology ( J:152840 )

• thinner at E10.5

growth/size/body

embryonic growth retardation ( J:152840 )

muscle

abnormal vascular smooth muscle morphology ( J:152840 )

• at E10.5, expression analysis suggests a decrease in the vascular smooth muscle cells surrounding the blood vessels

• at E10.5 the expression pattern of smooth muscle alpha actin is diffused and mislocalized

trabecula carnea hypoplasia ( J:152840 )

• seen at E10.5

thin myocardium ( J:152840 )

• seen at E10.5

homeostasis/metabolism

hemopericardium ( J:152840 )