About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm2(CUX1)Anep
targeted mutation 2, Alain Nepveu
MGI:4360515
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Hprt1tm2(CUX1)Anep/Hprt1+ either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB) MGI:4360518
ht2
 		Hprt1tm2(CUX1)Anep/Hprt1+ FVB.129P2-Hprt1tm2(CUX1)Anep MGI:4360520


Genotype
MGI:4360518
ht1
Allelic
Composition		 Hprt1tm2(CUX1)Anep/Hprt1+
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2(CUX1)Anep mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:113393 )
N
• unlike Hprt1tm1(Cutl1)Anep homozygotes, mice do not exhibit myeloproliferative disease




Genotype
MGI:4360520
ht2
Allelic
Composition		 Hprt1tm2(CUX1)Anep/Hprt1+
Genetic
Background		 FVB.129P2-Hprt1tm2(CUX1)Anep
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2(CUX1)Anep mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:152682 )
• after 2 years, 53% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 20% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (56%), adenosquamous carcinomas (22%), adenomyoepithelioma (11%), and tubular/acinar adenoma (11%)

integument
increased mammary gland tumor incidence ( J:152682 )
• after 2 years, 53% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 20% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (56%), adenosquamous carcinomas (22%), adenomyoepithelioma (11%), and tubular/acinar adenoma (11%)

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:152682 )
N
• mice exhibit normal mammary gland development
increased mammary gland tumor incidence ( J:152682 )
• after 2 years, 53% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 20% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (56%), adenosquamous carcinomas (22%), adenomyoepithelioma (11%), and tubular/acinar adenoma (11%)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
08/21/2024
MGI 6.24 		The Jackson Laboratory