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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm2(CUX1)Anep
targeted mutation 2, Alain Nepveu
MGI:4360515
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Hprt1tm2(CUX1)Anep/Hprt1+ either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB) MGI:4360518
ht2
 		Hprt1tm2(CUX1)Anep/Hprt1+ FVB.129P2-Hprt1tm2(CUX1)Anep MGI:4360520


Genotype
MGI:4360518
ht1
Allelic
Composition		 Hprt1tm2(CUX1)Anep/Hprt1+
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2(CUX1)Anep mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:113393 )
N
• unlike Hprt1tm1(Cutl1)Anep homozygotes, mice do not exhibit myeloproliferative disease




Genotype
MGI:4360520
ht2
Allelic
Composition		 Hprt1tm2(CUX1)Anep/Hprt1+
Genetic
Background		 FVB.129P2-Hprt1tm2(CUX1)Anep
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2(CUX1)Anep mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:152682 )
• after 2 years, 53% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 20% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (56%), adenosquamous carcinomas (22%), adenomyoepithelioma (11%), and tubular/acinar adenoma (11%)

integument
increased mammary gland tumor incidence ( J:152682 )
• after 2 years, 53% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 20% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (56%), adenosquamous carcinomas (22%), adenomyoepithelioma (11%), and tubular/acinar adenoma (11%)

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:152682 )
N
• mice exhibit normal mammary gland development
increased mammary gland tumor incidence ( J:152682 )
• after 2 years, 53% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 20% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (56%), adenosquamous carcinomas (22%), adenomyoepithelioma (11%), and tubular/acinar adenoma (11%)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory