immune system
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• unlike Hprt1tm1(Cutl1)Anep homozygotes, mice do not exhibit myeloproliferative disease
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Allele Symbol Allele Name Allele ID |
Hprt1tm2(CUX1)Anep targeted mutation 2, Alain Nepveu MGI:4360515 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• unlike Hprt1tm1(Cutl1)Anep homozygotes, mice do not exhibit myeloproliferative disease
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• after 2 years, 53% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 20% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (56%), adenosquamous carcinomas (22%), adenomyoepithelioma (11%), and tubular/acinar adenoma (11%)
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• after 2 years, 53% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 20% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (56%), adenosquamous carcinomas (22%), adenomyoepithelioma (11%), and tubular/acinar adenoma (11%)
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• mice exhibit normal mammary gland development
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• after 2 years, 53% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 20% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (56%), adenosquamous carcinomas (22%), adenomyoepithelioma (11%), and tubular/acinar adenoma (11%)
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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