Analysis Tools
mortality/aging
|
• shorter average life span (90 weeks)
|
|
• viable at birth with expected Mendelian ratios
• approximately 30% die before weaning
|
growth/size/body
|
• newborn have normal body weight
• approximately 20% lighter by the age of weaning
• low body weight persists through puberty and adulthood
• can not be rescued by a neuron specific wild-type human Atrophin-1 transgene Tg(Eno2-ATN1)1Tx
|
behavior/neurological
|
• adult mice consume less food
• normal rotarod test results
|
reproductive system
small testis
(
J:152709
)
 |
• in 5 of 8 mice
• apoptotic cells frequently found
• degeneration in aged mice
|
|
|
• low sperm counts in testes and epididymis
• apoptosis frequently observed in aged mutant testis
|
|
|
• gradually lose fertility and became sterile at the age around eight months
|
nervous system
| N |
• normal brain structure and morphology
• no neurodegeneration
|
endocrine/exocrine glands
small testis
(
J:152709
)
|
|
• in 5 of 8 mice
• apoptotic cells frequently found
• degeneration in aged mice
|
