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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apctm2Rfo
targeted mutation 2, Riccardo Fodde
MGI:4360657
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Apctm2Rfo/Apctm2Rfo B6.129P2-Apctm2Rfo MGI:4360682
ht2
 		Apctm2Rfo/Apc+ 129P2/OlaHsd-Apctm2Rfo MGI:4360686
ht3
 		Apctm2Rfo/Apc+ B6.129P2-Apctm2Rfo MGI:4360684
ht4
 		Apctm2Rfo/Apc+ (C57BL/6J x 129P2/OlaHsd)F1 MGI:4360685
cx5
 		Apctm2Rfo/Apc+
Smad4E6sad/Smad4+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:4360688
cx6
 		Apctm2Rfo/Apc+
Ctnnb1tm1.2Wvv/Ctnnb1+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:5430611


Genotype
MGI:4360682
hm1
Allelic
Composition		 Apctm2Rfo/Apctm2Rfo
Genetic
Background		 B6.129P2-Apctm2Rfo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Rfo mutation (1 available); any Apc mutation (158 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:151494 )
• during postnatal assessment, no mice are found




Genotype
MGI:4360686
ht2
Allelic
Composition		 Apctm2Rfo/Apc+
Genetic
Background		 129P2/OlaHsd-Apctm2Rfo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Rfo mutation (1 available); any Apc mutation (158 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Mammary adenocarcinomas from Apctm2Rfo/Apc+ mice

mortality/aging
premature death ( J:151494 )
• mice die prior to 18 weeks

neoplasm
increased gastrointestinal tumor incidence ( J:151494 )
• 29% of male mice develop gastrointestinal tumors
increased mammary adenocarcinoma incidence ( J:151494 )
• in 94% of female mice and 50% of male mice
increased liver tumor incidence ( J:151494 )
• in 11% of female mice and 29% of male mice

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:151494 )
• in 94% of female mice and 50% of male mice

liver/biliary system
increased liver tumor incidence ( J:151494 )
• in 11% of female mice and 29% of male mice

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:151494 )
• 29% of male mice develop gastrointestinal tumors

integument
increased mammary adenocarcinoma incidence ( J:151494 )
• in 94% of female mice and 50% of male mice




Genotype
MGI:4360684
ht3
Allelic
Composition		 Apctm2Rfo/Apc+
Genetic
Background		 B6.129P2-Apctm2Rfo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Rfo mutation (1 available); any Apc mutation (158 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Mammary adenocarcinomas from Apctm2Rfo/Apc+ mice

mortality/aging
premature death ( J:151494 )
• mice die prior to 16 weeks

neoplasm
increased mammary gland tumor incidence ( J:151494 )
• in 100% of virgin females and 29% of males
• all tumors exhibit squamous metaplasia
• however, mice do not exhibit an increased susceptibility to intestinal tumors
increased mammary adenocarcinoma incidence ( J:151494 )
• primary mammary adenocarcinomas metastasize to the lungs
increased liver tumor incidence ( J:151494 )
• in 29% of male mice
• all tumors exhibit squamous metaplasia

integument
increased mammary gland tumor incidence ( J:151494 )
• in 100% of virgin females and 29% of males
• all tumors exhibit squamous metaplasia
• however, mice do not exhibit an increased susceptibility to intestinal tumors
increased mammary adenocarcinoma incidence ( J:151494 )
• primary mammary adenocarcinomas metastasize to the lungs

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:151494 )
• in 100% of virgin females and 29% of males
• all tumors exhibit squamous metaplasia
• however, mice do not exhibit an increased susceptibility to intestinal tumors
increased mammary adenocarcinoma incidence ( J:151494 )
• primary mammary adenocarcinomas metastasize to the lungs

liver/biliary system
increased liver tumor incidence ( J:151494 )
• in 29% of male mice
• all tumors exhibit squamous metaplasia




Genotype
MGI:4360685
ht4
Allelic
Composition		 Apctm2Rfo/Apc+
Genetic
Background		 (C57BL/6J x 129P2/OlaHsd)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Rfo mutation (1 available); any Apc mutation (158 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Mammary adenocarcinomas from Apctm2Rfo/Apc+ mice

mortality/aging
premature death ( J:151494 )
• mice die prior to 21 weeks

neoplasm
increased metastatic potential ( J:204440 )
• lung micro- and macro-metastases
increased tumor incidence ( J:151494 )
• mice develop epidermal cysts with increased multiplicity in male mice
• however, mice do not exhibit an increased susceptibility to intestinal tumors
• all tumors exhibit squamous metaplasia
increased mammary gland tumor incidence ( J:151494 )
• in 86% of virgin females and 31% of males
increased mammary adenocarcinoma incidence ( J:151494 , J:204440 )
• primary mammary adenocarcinomas metastasize to the lungs (J:151494)
• mice develop metaplastic mammary adenocarcinoma, a subtype of triple-negative breast cancer (J:204440)
increased liver tumor incidence ( J:151494 )
• 31% of male mice develop liver tumors
• however, female mice do not develop liver tumors
• all tumors exhibit squamous metaplasia
increased desmoid tumor incidence ( J:151494 )
• mice develop desmoids with increased multiplicity in male mice

integument
increased mammary gland tumor incidence ( J:151494 )
• in 86% of virgin females and 31% of males
increased mammary adenocarcinoma incidence ( J:151494 , J:204440 )
• primary mammary adenocarcinomas metastasize to the lungs (J:151494)
• mice develop metaplastic mammary adenocarcinoma, a subtype of triple-negative breast cancer (J:204440)
epidermal cyst ( J:151494 )
• with increased mutliplicity in males

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:151494 )
• in 86% of virgin females and 31% of males
increased mammary adenocarcinoma incidence ( J:151494 , J:204440 )
• primary mammary adenocarcinomas metastasize to the lungs (J:151494)
• mice develop metaplastic mammary adenocarcinoma, a subtype of triple-negative breast cancer (J:204440)

growth/size/body
epidermal cyst ( J:151494 )
• with increased mutliplicity in males

liver/biliary system
increased liver tumor incidence ( J:151494 )
• 31% of male mice develop liver tumors
• however, female mice do not develop liver tumors
• all tumors exhibit squamous metaplasia

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:204440




Genotype
MGI:4360688
cx5
Allelic
Composition		 Apctm2Rfo/Apc+
Smad4E6sad/Smad4+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Rfo mutation (1 available); any Apc mutation (158 available)
Smad4E6sad mutation (0 available); any Smad4 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Phenotypic analysis of the compound in cis Apctm2Rfo/Apc+ Smad4E6sad/Smad4+ mouse model

neoplasm
increased gastrointestinal tumor incidence ( J:151494 )
• unlike in Apctm2Rfo heterozygotes, mice develop multiple gastro-intestinal tumors and adenomatous polyps
increased mammary adenocarcinoma incidence ( J:151494 )
• similar to in Apctm2Rfo heterozygotes

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:151494 )
• unlike in Apctm2Rfo heterozygotes, mice develop multiple gastro-intestinal tumors and adenomatous polyps

integument
increased mammary adenocarcinoma incidence ( J:151494 )
• similar to in Apctm2Rfo heterozygotes

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:151494 )
• similar to in Apctm2Rfo heterozygotes




Genotype
MGI:5430611
cx6
Allelic
Composition		 Apctm2Rfo/Apc+
Ctnnb1tm1.2Wvv/Ctnnb1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Rfo mutation (1 available); any Apc mutation (158 available)
Ctnnb1tm1.2Wvv mutation (0 available); any Ctnnb1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
rostral body truncation ( J:185942 )
• anterior truncation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory