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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Has2tm1.1Yama
targeted mutation 1.1, Yu Yamaguchi
MGI:4360705
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Has2tm1.1Yama/Has2tm1.1Yama
Tg(Prrx1-cre)1Cjt/0
involves: 129X1/SvJ * C57BL/6 * FVB/N * SJL/J MGI:4360706


Genotype
MGI:4360706
cn1
Allelic
Composition
Has2tm1.1Yama/Has2tm1.1Yama
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * FVB/N * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Has2tm1.1Yama mutation (0 available); any Has2 mutation (35 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• the proximal phalanges of digits 2 and 5 are duplicated on all 4 limbs
• the proximal phalanges of digits 2 and 5 are misshapen on the forelimbs
• at P0 about 53% of mice show partial duplications of the proximal phalanges of digits 3 and 4
• at E16.5 the shoulder and elbow joints are smaller, less extensive, and contain numerous cells unlike in wild-type controls
• at E16.5 the carpal and phalangeal joint regions are larger than normal, filled with closely packed cells and lack distinct joint cavities
• at E16.5 and P3 all of the skeletal elements are about half the length of wild-type littermates

behavior/neurological
• move in a manner similar to pinnipeds

skeleton
• the proximal phalanges of digits 2 and 5 are duplicated on all 4 limbs
• the proximal phalanges of digits 2 and 5 are misshapen on the forelimbs
• at P0 about 53% of mice show partial duplications of the proximal phalanges of digits 3 and 4
• staining analysis indicates that deposition of proteoglycans and glycosaminoglycans is reduced
• growth plates are severely disturbed and disorganized with increased cell density reflecting a decreased in the amount of cartilage matrix
• at P9 the hypertrophic zone fails to differentiate in the central region of the growth plate and vascular invasion of the growth plate is not seen
• no secondary ossification center is seen at P21
• columnar organization is absent
• in long bone epiphyseal plates the chondrocytes are small, round and randomly distributed
• decrease in the number of hypertrophic chondrocytes in the long bone epiphyseal plates
• however, there is little to no difference in chondrocyte proliferation in the epiphyseal plates
• at E16.5 the carpal and phalangeal joint regions are larger than normal, filled with closely packed cells and lack distinct joint cavities
• at E16.5 the shoulder and elbow joints are smaller, less extensive, and contain numerous cells unlike in wild-type controls
• formation of synovial joint cavities is defective in the proximal joints of the limbs





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory