neoplasm
• metastasis is much more frequent (6 out of 14 cases) than when Dcc is un-mutated or mutation is heterozygous
• metastases are found in draining lymph nodes and/or lungs
|
• high tumor incidence (80%) of mammary tumors regardless of presence or zygosity of Dcc mutation
• single or multiple independent tumors
|
• solid tumors with clear demarcations
|
• in mammary glands
|
• tumor latency of mammary tumors is not modified by the presence or zygosity of Dcc mutation
|
cellular
• tumor cells in culture cannot be induced to apoptosis
|
endocrine/exocrine glands
integument