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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dcctm1Nki
targeted mutation 1, The Netherlands Cancer Institute
MGI:4360737
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Dcctm1Nki/Dcctm1Nki
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/?
involves: 129P2/OlaHsd * FVB/N MGI:5308805


Genotype
MGI:5308805
cn1
Allelic
Composition
Dcctm1Nki/Dcctm1Nki
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/?
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcctm1Nki mutation (0 available); any Dcc mutation (76 available)
Tg(KRT14-cre)8Brn mutation (4 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• metastasis is much more frequent (6 out of 14 cases) than when Dcc is un-mutated or mutation is heterozygous
• metastases are found in draining lymph nodes and/or lungs
• high tumor incidence (80%) of mammary tumors regardless of presence or zygosity of Dcc mutation
• single or multiple independent tumors
• solid tumors with clear demarcations
• tumor latency of mammary tumors is not modified by the presence or zygosity of Dcc mutation

cellular
• tumor cells in culture cannot be induced to apoptosis

endocrine/exocrine glands

integument





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory