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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Trp53)1Srn
transgene insertion 1, Manuel Serrano
MGI:4360913
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Trp53)1Srn/0
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:5751688
tg2
 		Tg(Trp53)1Srn/Tg(Trp53)1Srn involves: C57BL/6 * CBA MGI:5751687
tg3
 		Tg(Trp53)1Srn/0 involves: C57BL/6 * CBA MGI:5751684


Genotype
MGI:5751688
cx1
Allelic
Composition		 Tg(Trp53)1Srn/0
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Trp53)1Srn mutation (1 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased thymocyte apoptosis ( J:80311 )
• radiation-induced apoptosis in the thymus is increased as compared to homozygous Trp53tm1Tyj mice, but is decreased as compared to wild-type, and is similar to heterozygous Trp53tm1Tyj mice

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:80311 )
• radiation-induced apoptosis in the thymus is increased as compared to homozygous Trp53tm1Tyj mice, but is decreased as compared to wild-type, and is similar to heterozygous Trp53tm1Tyj mice

hematopoietic system
decreased thymocyte apoptosis ( J:80311 )
• radiation-induced apoptosis in the thymus is increased as compared to homozygous Trp53tm1Tyj mice, but is decreased as compared to wild-type, and is similar to heterozygous Trp53tm1Tyj mice

immune system
decreased thymocyte apoptosis ( J:80311 )
• radiation-induced apoptosis in the thymus is increased as compared to homozygous Trp53tm1Tyj mice, but is decreased as compared to wild-type, and is similar to heterozygous Trp53tm1Tyj mice

mortality/aging
premature death ( J:80311 )
• average lifespan is 9.5 months
• mice live longer than homozygous Trp53tm1Tyj mice (4.5 months)
• but, not as long as heterozygous Trp53tm1Tyj mice (14 months)




Genotype
MGI:5751687
tg2
Allelic
Composition		 Tg(Trp53)1Srn/Tg(Trp53)1Srn
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Trp53)1Srn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:80311 )
N
• survival at 2 years of age is similar to wild-type (respectively 75% and 78%)




Genotype
MGI:5751684
tg3
Allelic
Composition		 Tg(Trp53)1Srn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Trp53)1Srn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor incidence ( J:80311 )
• 17% of mice exhibit tumors following spontaneous death as compared to 47% of wild-type mice
decreased incidence of tumors by chemical induction ( J:80311 )
• mice develop fewer 3MC-induced fibrosarcomas as compared to wild-type; 8/12 mice are tumor free, 11/12 wild-type mice develop fibrosarcomas
• mice develop fewer BBN-induced urinary bladder carcinomas as compared to wild-type; tumors that develop are monofocal rather than multifiocal and develop later

immune system
increased thymocyte apoptosis ( J:80311 )
• increased induction of apoptosis in thymus following whole body irradiation

mortality/aging
mortality/aging ( J:80311 )
N
• survival at 2 years of age is similar to wild-type (respectively 70% and 78%)
• mice exhibit signs of aging (hair growth, lordokyphosis, skin thickness and osteoporosis) similar to wild-type
• Mendelian ratios from a hemizygote x wild type matings are as predicted

endocrine/exocrine glands
increased thymocyte apoptosis ( J:80311 )
• increased induction of apoptosis in thymus following whole body irradiation

cellular
increased thymocyte apoptosis ( J:80311 )
• increased induction of apoptosis in thymus following whole body irradiation

hematopoietic system
increased thymocyte apoptosis ( J:80311 )
• increased induction of apoptosis in thymus following whole body irradiation

reproductive system
reproductive system phenotype ( J:80311 )
N
• hemizygote x wild type matings produce litters sizes similar to wild-type

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:80311 )
• mice develop fewer 3MC-induced fibrosarcomas as compared to wild-type; 8/12 mice are tumor free, 11/12 wild-type mice develop fibrosarcomas
• mice develop fewer BBN-induced urinary bladder carcinomas as compared to wild-type; tumors that develop are monofocal rather than multifiocal and develop later




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory