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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(Wnk1)Clhu
targeted mutation 1, Chou-Long Huang
MGI:4360975
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+
Kdrtm1(cre)Sato/Kdr+
Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex 		involves: 129S1/Sv * 129S5/SvEvBrd MGI:4360981
cn2
 		Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+
Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Tg(Tek-cre)12Flv/0 		involves: 129S5/SvEvBrd * C3H * C57BL/6 MGI:4360980
cn3
 		Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+
Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S5/SvEvBrd * C57BL/6 * CBA MGI:4360982


Genotype
MGI:4360981
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+
Kdrtm1(cre)Sato/Kdr+
Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Genetic
Background		 involves: 129S1/Sv * 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Wnk1)Clhu mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Kdrtm1(cre)Sato mutation (1 available); any Kdr mutation (74 available)
Wnk1Gt(OST38262)Lex mutation (1 available); any Wnk1 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:152906 )
N
• unlike single Wnk1 homozygotes, heart morphology is grossly normal

embryo
abnormal embryo development ( J:152906 )
• the incidence of abnormal embryos is increased compared to controls indicating only a partial rescue




Genotype
MGI:4360980
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+
Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129S5/SvEvBrd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Wnk1)Clhu mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Tek-cre)12Flv mutation (1 available)
Wnk1Gt(OST38262)Lex mutation (1 available); any Wnk1 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:152906 )
• all but one, died within 1 day of birth
• however, the early lethality seen in single Wnk1 homozygotes does not occur

cardiovascular system
cardiovascular system phenotype ( J:152906 )
N
• unlike single Wnk1 homozygotes, heart morphology is grossly normal at E15.5

embryo
abnormal embryo development ( J:152906 )
• the incidence of abnormal embryos is increased compared to controls indicating only a partial rescue




Genotype
MGI:4360982
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+
Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Gt(ROSA)26Sortm1(Wnk1)Clhu mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Wnk1Gt(OST38262)Lex mutation (1 available); any Wnk1 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis ( J:152906 )
• expression of Wnk1 in the somatic embryonic cells fails to rescue the phenotypes seen in Wnk1 null embryos




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory