Phenotypes associated with this allele

• Allele Symbol: Tg(MMTV-Erbb2*,-cre)1Mul
• Allele Name: transgene insertion 1, William J Muller
• Allele ID: MGI:4361017
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Shc1^tm9Paw/Shc1^tm9Paw Tg(MMTV-Erbb2*,-cre)1Mul/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:4361923
cn2	Stk11^tm1Rdp/Stk11^tm1Rdp Tg(MMTV-Erbb2*,-cre)1Mul/0	involves: 129S6/SvEvTac * C57BL/6	MGI:5496896
cn3	Stat1^tm1Mam/Stat1^tm1Mam Tg(MMTV-Erbb2*,-cre)1Mul/0	involves: 129S/SvEv * FVB	MGI:4821942
cn4	Dock1^tm2.1Jfco/Dock1^tm2.1Jfco Tg(MMTV-Erbb2*,-cre)1Mul/0	involves: C57BL/6 * FVB/NJ	MGI:5515765
cn5	Dock1^tm2.1Jfco/Dock1^+ Tg(MMTV-Erbb2*,-cre)1Mul/0	involves: C57BL/6 * FVB/NJ	MGI:5515766
tg6	Tg(MMTV-Erbb2*,-cre)1Mul/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:4361922
tg7	Tg(MMTV-Erbb2*,-cre)1Mul/0	involves: FVB	MGI:5496897

Genotype
MGI:4361923

cn1

• Allelic Composition: Shc1^tm9Paw/Shc1^tm9Paw; Tg(MMTV-Erbb2*,-cre)1Mul/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:133325 )

N • mammary tumor development is completely ablated

reproductive system

reproductive system phenotype ( J:133325 )

N • mammary glands show no hyperplastic or neoplastic lesions within mammary epithelial cells mammary glands show no hyperplastic or neoplastic lesions within mammary epithelial cells

endocrine/exocrine glands

abnormal mammary gland morphology ( J:133325 )

♀ • compared to wild-type FVB controls, proliferative index of mammary epithelial cells is strongly reduced and apoptotic index is significantly increased

integument

abnormal mammary gland morphology ( J:133325 )

♀ • compared to wild-type FVB controls, proliferative index of mammary epithelial cells is strongly reduced and apoptotic index is significantly increased

Genotype
MGI:5496896

cn2

• Allelic Composition: Stk11^tm1Rdp/Stk11^tm1Rdp; Tg(MMTV-Erbb2*,-cre)1Mul/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

neoplasm

increased mammary gland tumor incidence ( J:198481 )

♀ • 50% of nulliparous female mice develop tumors by 147 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)

decreased tumor latency ( J:198481 )

♀ • 50% of nulliparous female mice develop tumors by 147 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)

endocrine/exocrine glands

abnormal mammary gland morphology ( J:198481 )

♀ • tissue adjacent to primary tumors display abnormal luminal growth, possibly an early sign of tumors

increased mammary gland tumor incidence ( J:198481 )

♀ • 50% of nulliparous female mice develop tumors by 147 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)

integument

abnormal mammary gland morphology ( J:198481 )

♀ • tissue adjacent to primary tumors display abnormal luminal growth, possibly an early sign of tumors

increased mammary gland tumor incidence ( J:198481 )

♀ • 50% of nulliparous female mice develop tumors by 147 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)

Genotype
MGI:4821942

cn3

• Allelic Composition: Stat1^tm1Mam/Stat1^tm1Mam; Tg(MMTV-Erbb2*,-cre)1Mul/0
• Genetic Background: involves: 129S/SvEv * FVB

neoplasm

decreased tumor latency ( J:169262 )

• median time to tumor onset is 49 weeks compared with 62 weeks for Tg(MMTV-Erbb2*,-cre)1Mul mice

Genotype
MGI:5515765

cn4

• Allelic Composition: Dock1^tm2.1Jfco/Dock1^tm2.1Jfco; Tg(MMTV-Erbb2*,-cre)1Mul/0
• Genetic Background: involves: C57BL/6 * FVB/NJ

neoplasm

increased mammary gland tumor incidence ( J:196659 )

• with later onset but fewer large tumors onset and reduced total tumor volume than in Tg(MMTV-Erbb2*,-cre)1Mul mice

• reduced intraepithelial neoplastic lesions

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors

decreased metastatic potential ( J:196659 )

• 5-fold compared with Tg(MMTV-Erbb2*,-cre)1Mul mice

• all lung metastases are confined to the lung vasculature

decreased tumor growth/size ( J:196659 )

• fewer large tumors onset and reduced total tumor volume than in Tg(MMTV-Erbb2*,-cre)1Mul mice

• decreased proliferation and increased apoptosis in mammary gland tumors

• however, tumor angiogenesis is normal

increased tumor latency ( J:196659 )

• later onset onset than in Tg(MMTV-Erbb2*,-cre)1Mul mice

cellular

increased apoptosis ( J:196659 )

• in mammary gland tumors

decreased cell proliferation ( J:196659 )

• in mammary gland tumors

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:196659 )

• with later onset but fewer large tumors onset and reduced total tumor volume than in Tg(MMTV-Erbb2*,-cre)1Mul mice

• reduced intraepithelial neoplastic lesions

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors

integument

increased mammary gland tumor incidence ( J:196659 )

• with later onset but fewer large tumors onset and reduced total tumor volume than in Tg(MMTV-Erbb2*,-cre)1Mul mice

• reduced intraepithelial neoplastic lesions

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors

Genotype
MGI:5515766

cn5

• Allelic Composition: Dock1^tm2.1Jfco/Dock1⁺; Tg(MMTV-Erbb2*,-cre)1Mul/0
• Genetic Background: involves: C57BL/6 * FVB/NJ

neoplasm

increased mammary gland tumor incidence ( J:196659 )

• with later onset than in Tg(MMTV-Erbb2*,-cre)1Mul mice

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors

increased tumor latency ( J:196659 )

• later onset than in Tg(MMTV-Erbb2*,-cre)1Mul mice

integument

increased mammary gland tumor incidence ( J:196659 )

• with later onset than in Tg(MMTV-Erbb2*,-cre)1Mul mice

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:196659 )

• with later onset than in Tg(MMTV-Erbb2*,-cre)1Mul mice

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors

Genotype
MGI:4361922

tg6

• Allelic Composition: Tg(MMTV-Erbb2*,-cre)1Mul/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:133325 )

• tumors develop after 100 days of age

integument

increased mammary gland tumor incidence ( J:133325 )

• tumors develop after 100 days of age

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:133325 )

• tumors develop after 100 days of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:133325

Genotype
MGI:5496897

tg7

• Allelic Composition: Tg(MMTV-Erbb2*,-cre)1Mul/0
• Genetic Background: involves: FVB

neoplasm

increased mammary gland tumor incidence ( J:198481 )

♀ • 50% of nulliparous female mice develop tumors by 197 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)

decreased tumor latency ( J:198481 )

♀ • 50% of nulliparous female mice develop tumors by 197 days of age, compared to wild-type females which do not develop tumors (during period of observation)

endocrine/exocrine glands

abnormal mammary gland morphology ( J:198481 )

♀ • tissue adjacent to primary tumors display abnormal luminal growth, possibly an early sign of tumors

increased mammary gland tumor incidence ( J:198481 )

♀ • 50% of nulliparous female mice develop tumors by 197 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)

integument

abnormal mammary gland morphology ( J:198481 )

♀ • tissue adjacent to primary tumors display abnormal luminal growth, possibly an early sign of tumors

increased mammary gland tumor incidence ( J:198481 )

♀ • 50% of nulliparous female mice develop tumors by 197 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)