Phenotypes associated with this allele

• Allele Symbol: Hunk^tm1Lach
• Allele Name: targeted mutation 1, Lewis A Chodosh
• Allele ID: MGI:4361146
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hunk^tm1Lach/Hunk^tm1Lach	involves: 129P2/OlaHsd	MGI:4361149
cx2	Hunk^tm1Lach/Hunk^tm1Lach Tg(MMTV-Myc)#Led/0	involves: 129P2/OlaHsd * C57BL/6J * CD-1	MGI:4361150
cx3	Hunk^tm1Lach/Hunk^+ Tg(MMTV-Myc)#Led/0	involves: 129P2/OlaHsd * C57BL/6J * CD-1	MGI:4361151

Genotype
MGI:4361149

hm1

• Allelic Composition: Hunk^tm1Lach/Hunk^tm1Lach
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:153075 )

• viable and fertile with normal longevity, no gross morphological abnormalities and no alteration in spontaneous tumor formation

Genotype
MGI:4361150

cx2

• Allelic Composition: Hunk^tm1Lach/Hunk^tm1Lach; Tg(MMTV-Myc)#Led/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

neoplasm

decreased metastatic potential ( J:153075 )

• while tumor latency, multiplicity and growth rate are similar to controls, the fraction of mice with lung metastases is about 5 fold lower compared to transgenic mice wild-type for Hunk

• a decrease in metastases is also seen when primary tumors are transplanted in nude mice

Genotype
MGI:4361151

cx3

• Allelic Composition: Hunk^tm1Lach/Hunk⁺; Tg(MMTV-Myc)#Led/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

neoplasm

decreased metastatic potential ( J:153075 )

• while tumor latency, multiplicity and growth rate are similar to controls, the fraction of mice with lung metastases is reduced compared to transgenic mice wild-type for Hunk but increased compared to transgenic mice that are homozygous for the mutant allele