Phenotypes associated with this allele

• Allele Symbol: Wnt2^{tm1.1(rtTA)Eem}
• Allele Name: targeted mutation 1.1, Edward E Morrisey
• Allele ID: MGI:4361155
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt2^tm1.1(rtTA)Eem/Wnt2^tm1.1(rtTA)Eem	involves: 129X1/SvJ * C57BL/6	MGI:4361158
cx2	Wnt2^tm1.1(rtTA)Eem/Wnt2^tm1.1(rtTA)Eem Wnt2b^tm1.1Eem/Wnt2b^tm1.1Eem	involves: 129X1/SvJ * C57BL/6	MGI:4361161

Genotype
MGI:4361158

hm1

• Allelic Composition: Wnt2^{tm1.1(rtTA)Eem}/Wnt2^{tm1.1(rtTA)Eem}
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:153098 )

• most mice die shortly after birth

respiratory system

abnormal lung vasculature morphology ( J:153098 )

• vascular endothelial plexus is dilated and dysfunctional

decreased mesenchymal cell proliferation involved in lung development ( J:153098 )

• mesenchymal cell proliferation in the lungs is reduced compared with wild-type mice

abnormal lung-associated mesenchyme development ( J:153098 )

• however, lung branching of terminal airways is normal

• mice exhibit poor development of lung mesenchyme

pulmonary hypoplasia ( J:153098 )

• at E10.5 to E18.5, mice exhibit lung hypoplasia compared with wild-type mice

abnormal respiratory system physiology ( J:153098 )

• epithelial and mesenchymal cell proliferation in the lungs is reduced compared with wild-type mice

homeostasis/metabolism

cyanosis ( J:153098 )

cardiovascular system

abnormal lung vasculature morphology ( J:153098 )

• vascular endothelial plexus is dilated and dysfunctional

cellular

decreased mesenchymal cell proliferation involved in lung development ( J:153098 )

• mesenchymal cell proliferation in the lungs is reduced compared with wild-type mice

Genotype
MGI:4361161

cx2

• Allelic Composition: Wnt2^{tm1.1(rtTA)Eem}/Wnt2^{tm1.1(rtTA)Eem}; Wnt2b^tm1.1Eem/Wnt2b^tm1.1Eem
• Genetic Background: involves: 129X1/SvJ * C57BL/6

respiratory system

absent lungs ( J:153098 )

• at E11.5 and E14.5, mice exhibit complete lung agenesis

absent trachea ( J:153098 )

• at E11.5 and E14.5, mice lack tracheal development