Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko transgene insertion 8, Makoto Mark Taketo MGI:4361186 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some mice die between 25 and 50 weeks of age due to tumors
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• 100% penetrance of dysplastic gastric tumors in mice older than 20 weeks of age, with tumors consisting of dysplastic epithelial cells with nuclear stratification and irregularly branched tubules
(J:116782)
• tumors resemble human intestinal-type gastric cancer and gastric adenocarcinoma
(J:116782)
• tumor invasion into the smooth muscle layers is seen in 50%, 75% and 100% of mutants at 20, 30, and 50 weeks of age, respectively
(J:116782)
• tumors exhibit an accumulation of macrophages and increased angiogenesis
(J:116782)
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• hyperproliferation of gastric epithelial cells
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• mutants exhibit mucous metaplasia as early as 5 weeks of age, before dysplastic tumor formation
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• 100% penetrance of dysplastic gastric tumors in mice older than 20 weeks of age, with tumors consisting of dysplastic epithelial cells with nuclear stratification and irregularly branched tubules
(J:116782)
• tumors resemble human intestinal-type gastric cancer and gastric adenocarcinoma
(J:116782)
• tumor invasion into the smooth muscle layers is seen in 50%, 75% and 100% of mutants at 20, 30, and 50 weeks of age, respectively
(J:116782)
• tumors exhibit an accumulation of macrophages and increased angiogenesis
(J:116782)
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| stomach cancer | DOID:10534 |
OMIM:613659 |
J:116782 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mucous cell metaplasia is seen in the proximal glandular stomach as early as 5 weeks of age
• however, mutants do not show dysplastic signs or tumor development at 50 weeks of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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