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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc2a9tm1.1Thor
targeted mutation 1.1, Bernard Thorens
MGI:4361276
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Slc2a9tm1.1Thor/Slc2a9tm1.1Thor
Albtm1(cre/ERT2)Mtz/Alb+
involves: 129S2/SvPas * C57BL/6 * C57BL/6N MGI:4361281
cn2
Slc2a9tm1.1Thor/Slc2a9+
Albtm1(cre/ERT2)Mtz/Alb+
involves: 129S2/SvPas * C57BL/6 * C57BL/6N MGI:4361282


Genotype
MGI:4361281
cn1
Allelic
Composition
Slc2a9tm1.1Thor/Slc2a9tm1.1Thor
Albtm1(cre/ERT2)Mtz/Alb+
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Albtm1(cre/ERT2)Mtz mutation (2 available); any Alb mutation (97 available)
Slc2a9tm1.1Thor mutation (2 available); any Slc2a9 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 2 weeks after tamoxifen treatment, plasma urate levels are increased
• after tamoxifen treatment
• mild increase in Mg2+ fractional excretion after tamoxifen treatment
• after tamoxifen treatment, urine osmolality is decreased and water deprivation fails to increase urine osmolality
• after tamoxifen treatment
• mild increase in urine Pi levels after tamoxifen treatment
• 2 weeks after tamoxifen treatment, urine urate levels are increased about 20 fold
• after tamoxifen treatment, fractional excretion of urate is about 25% in both males and females and daily urate excretion is elevated

renal/urinary system
N
• unlike in germline null mice, liver specific null mice have normal kidney histology
• after tamoxifen treatment
• mild increase in Mg2+ fractional excretion after tamoxifen treatment
• after tamoxifen treatment, urine osmolality is decreased and water deprivation fails to increase urine osmolality
• after tamoxifen treatment
• mild increase in urine Pi levels after tamoxifen treatment
• 2 weeks after tamoxifen treatment, urine urate levels are increased about 20 fold
• after tamoxifen treatment, fractional excretion of urate is about 25% in both males and females and daily urate excretion is elevated
• after tamoxifen treatment, urine volume is increased about 2 fold




Genotype
MGI:4361282
cn2
Allelic
Composition
Slc2a9tm1.1Thor/Slc2a9+
Albtm1(cre/ERT2)Mtz/Alb+
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Albtm1(cre/ERT2)Mtz mutation (2 available); any Alb mutation (97 available)
Slc2a9tm1.1Thor mutation (2 available); any Slc2a9 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mild increase in Mg2+ fractional excretion after tamoxifen treatment
• mild increase in urine Pi levels after tamoxifen treatment

renal/urinary system
• mild increase in Mg2+ fractional excretion after tamoxifen treatment
• mild increase in urine Pi levels after tamoxifen treatment





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory