homeostasis/metabolism
• 2 weeks after tamoxifen treatment, plasma urate levels are increased
|
• after tamoxifen treatment
|
• mild increase in Mg2+ fractional excretion after tamoxifen treatment
|
• after tamoxifen treatment, urine osmolality is decreased and water deprivation fails to increase urine osmolality
|
• after tamoxifen treatment
|
• mild increase in urine Pi levels after tamoxifen treatment
|
• 2 weeks after tamoxifen treatment, urine urate levels are increased about 20 fold
• after tamoxifen treatment, fractional excretion of urate is about 25% in both males and females and daily urate excretion is elevated
|
renal/urinary system
N |
• unlike in germline null mice, liver specific null mice have normal kidney histology
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• after tamoxifen treatment
|
• mild increase in Mg2+ fractional excretion after tamoxifen treatment
|
• after tamoxifen treatment, urine osmolality is decreased and water deprivation fails to increase urine osmolality
|
• after tamoxifen treatment
|
• mild increase in urine Pi levels after tamoxifen treatment
|
• 2 weeks after tamoxifen treatment, urine urate levels are increased about 20 fold
• after tamoxifen treatment, fractional excretion of urate is about 25% in both males and females and daily urate excretion is elevated
|