Phenotypes associated with this allele

• Allele Symbol: Grin1^tm1.1Ese
• Allele Name: targeted mutation 1.1, Effat S Emamian
• Allele ID: MGI:4361333
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin1^tm1.1Ese/Grin1^tm1.1Ese	involves: C57BL/6	MGI:4361336

Genotype
MGI:4361336

hm1

• Allelic Composition: Grin1^tm1.1Ese/Grin1^tm1.1Ese
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal glutamate-mediated receptor currents ( J:153043 )

• the ratio of NMDAR- to AMPAR-mediated synaptic transmission is decreased compared to in wild-type mice

reduced AMPA-mediated synaptic currents ( J:153043 )

• reduced in amplitude and frequency

reduced long-term potentiation ( J:153043 )

abnormal miniature excitatory postsynaptic currents ( J:153043 )

• the interevent intervals of miniature excitatory postsynaptic currents is longer than in wild-type mice

decreased prepulse inhibition ( J:153043 )

• mice exhibit decreased prepulse inhibition for prepulse intensities of 8 or 12 dBa compared with wild-type mice

• however, baseline accoustic startle is normal

behavior/neurological

decreased vertical activity ( J:153043 )

• in test 1 but not subsequent tests

abnormal social investigation ( J:153043 )

• mice fail to exhibit a decline in the number of social interactions towards the repeatedly introduced stimulus mouse and also fail to show an increase in social investigation towards the novel stimulus mouse unlike wild-type mice

• however, olfactory responsiveness is normal