Phenotypes associated with this allele

• Allele Symbol: Nkx3-1^tm3(cre)Mms
• Allele Name: targeted mutation 3, Michael M Shen
• Allele ID: MGI:4361334
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Klf6^tm1Fjs/Klf6^tm1Fjs Nkx3-1^tm3(cre)Mms/Nkx3-1^+	involves: 129/Sv * C57BL/6	MGI:4361338

Genotype
MGI:4361338

cn1

• Allelic Composition: Klf6^tm1Fjs/Klf6^tm1Fjs; Nkx3-1^tm3(cre)Mms/Nkx3-1⁺
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormality in ductal branching in the Klf6^tm1Fjs/Klf6^tm1Fjs Nkx3-1^tm3(cre)Mms/Nkx3-1⁺ prostate epithelium

endocrine/exocrine glands

abnormal prostate gland anterior lobe morphology ( J:153183 )

♂ • lacks secondary branches

♂ • epithelial infolding is significantly reduced resulting in a defined layer of epithelial cells outlining the main ducts

abnormal prostate gland branching morphogenesis ( J:153183 )

♂ • impaired branching is seen in the anterior prostate in all males by P5

♂ • at 6 months and 1 year of age most mature prostates still lack secondary branching in the anterior prostate

♂ • branching defects are not as apparent in the dorsal and ventral prostates possibly as a result of less efficient Cre mediated recombination

abnormal prostate gland duct morphology ( J:153183 )

♂ • in the dorsal and ventral prostates the luminal spaces of the ducts are increased

♂ • in the anterior prostate, epithelial infolding is significantly reduced resulting in a defined layer of epithelial cells outlining the main ducts

reproductive system

abnormal prostate gland anterior lobe morphology ( J:153183 )

♂ • lacks secondary branches

♂ • epithelial infolding is significantly reduced resulting in a defined layer of epithelial cells outlining the main ducts

abnormal prostate gland branching morphogenesis ( J:153183 )

♂ • impaired branching is seen in the anterior prostate in all males by P5

♂ • at 6 months and 1 year of age most mature prostates still lack secondary branching in the anterior prostate

♂ • branching defects are not as apparent in the dorsal and ventral prostates possibly as a result of less efficient Cre mediated recombination

abnormal prostate gland duct morphology ( J:153183 )

♂ • in the dorsal and ventral prostates the luminal spaces of the ducts are increased

♂ • in the anterior prostate, epithelial infolding is significantly reduced resulting in a defined layer of epithelial cells outlining the main ducts