Phenotypes associated with this allele

• Allele Symbol: Map3k4^byg
• Allele Name: boygirl
• Allele ID: MGI:4361339
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k4^byg/Map3k4^byg	involves: C3H/HeH * C57BL/6J	MGI:4361423
ht2	Map3k4^byg/Map3k4^tm1Flv	involves: 129S6/SvEvTac * C3H/HeH * C57BL/6J	MGI:4361427
cx3	Del(17)T^hp/Map3k4^byg	involves: AKR/J * C3H/HeH * C57BL/6J	MGI:4361425

Genotype
MGI:4361423

hm1

• Allelic Composition: Map3k4^byg/Map3k4^byg
• Genetic Background: involves: C3H/HeH * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Exencephaly, spina bifida, mild edema, and gonadal abnormalities with XY gonadal sex reversal in Map3k4^byg/Map3k4^byg embryos

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:153050 )

• after E15.5

reproductive system

reproductive system phenotype ( J:153050 )

N • XX gonads appear normal

abnormal testis development ( J:153050 )

• testes development is disrupted as confirmed by abnormal expression of the Sertoli cell marker Sox9

abnormal testis cord formation ( J:153050 )

• some mice exhibit a reduction in the number or absence of testes cords and irregular morphology compared with wild-type mice

absent testis cords ( J:153050 )

• in some mice

abnormal primary sex determination ( J:153050 )

• cultured gonadal XY explants fail to form testis cords or express testis-specific markers but express ovarian markers unlike wild-type samples

• in XY gonads, proliferation of cells in the coelomic region is severely reduced compared to in wild-type mice

• in XY gonads, migration of mesonephric cells to form testes cords is impaired compared to in wild-type mice

ovotestis ( J:153050 )

• in XY mice

primary sex reversal ( J:153050 )

• XY mice develop ovotestis that develop testes cords at the central portion while the poles are ovarian in appearance and marker expression

nervous system

spina bifida ( J:153050 )

exencephaly ( J:153050 )

homeostasis/metabolism

edema ( J:153050 )

• mild

endocrine/exocrine glands

abnormal testis development ( J:153050 )

• testes development is disrupted as confirmed by abnormal expression of the Sertoli cell marker Sox9

abnormal testis cord formation ( J:153050 )

• some mice exhibit a reduction in the number or absence of testes cords and irregular morphology compared with wild-type mice

absent testis cords ( J:153050 )

• in some mice

embryo

spina bifida ( J:153050 )

Genotype
MGI:4361427

ht2

• Allelic Composition: Map3k4^byg/Map3k4^tm1Flv
• Genetic Background: involves: 129S6/SvEvTac * C3H/HeH * C57BL/6J

reproductive system

primary sex reversal ( J:153050 )

• XY gonads are ovarian in appearance

nervous system

abnormal neural tube morphology ( J:153050 )

• at E14.5

embryo

abnormal neural tube morphology ( J:153050 )

• at E14.5

Genotype
MGI:4361425

cx3

• Allelic Composition: Del(17)T^hp/Map3k4^byg
• Genetic Background: involves: AKR/J * C3H/HeH * C57BL/6J

XY embryos doubly heterozygous for Map3k4^byg and Del(17)T^hp exhibit a range of defects of gonad development similar to Map3k4^byg homozygotes

reproductive system

abnormal testis cord formation ( J:153050 )

• testes exhibit regions lacking clear cord morphology unlike in wild-type mice

primary sex reversal ( J:153050 )

• at E13.5 and E14.5, XY gonads exhibit disruption in cord morphology or gonadal sex reversal

nervous system

abnormal neural tube morphology ( J:153050 )

endocrine/exocrine glands

abnormal testis cord formation ( J:153050 )

• testes exhibit regions lacking clear cord morphology unlike in wild-type mice

embryo

abnormal neural tube morphology ( J:153050 )