Phenotypes associated with this allele

• Allele Symbol: Ifngr1^tm1.1Rost
• Allele Name: targeted mutation 1.1, Robyn Starr
• Allele ID: MGI:4361521
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifngr1^tm1.1Rost/Ifngr1^tm1.1Rost	involves: BALB/cJ * C57BL/6	MGI:4361525

Genotype
MGI:4361525

hm1

• Allelic Composition: Ifngr1^tm1.1Rost/Ifngr1^tm1.1Rost
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:152785 )

N • mice exhibit normal lymphocyte cellularity

decreased circulating interferon-gamma level ( J:152785 )

• 6 hours following treatment with alphaGalCer compared to in similarly treated wild-type mice

decreased circulating interleukin-12 level ( J:152785 )

• 6 hours following treatment with alphaGalCer compared to in similarly treated wild-type mice

abnormal chemokine level ( J:152785 )

• after 6 and 12 hours, alphaGalCer-treated mice exhibit an increase in serum CCXL9 levels compared with similarly treated wild-type mice

• after 72 hours, CXCL9 production by alphaGalCer- or IFN-gamma-stimulated splenocytes is increased compared that of similarly treated wild-type cells

neoplasm

decreased metastatic potential ( J:152785 )

• following treatment with alphaGalCer, fewer B16F10 tumors metastasize to the lungs than in similarly treated wild-type mice

• mice exhibit reduced metastasis of B16F10 tumors to the lungs compared with wild-type mice

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:152785 )

• 6 hours following treatment with alphaGalCer compared to in similarly treated wild-type mice

decreased circulating interleukin-12 level ( J:152785 )

• 6 hours following treatment with alphaGalCer compared to in similarly treated wild-type mice

abnormal chemokine level ( J:152785 )

• after 6 and 12 hours, alphaGalCer-treated mice exhibit an increase in serum CCXL9 levels compared with similarly treated wild-type mice

• after 72 hours, CXCL9 production by alphaGalCer- or IFN-gamma-stimulated splenocytes is increased compared that of similarly treated wild-type cells