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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Gfap-gp120)10Lms
transgene insertion 10, Lennart Mucke
MGI:4361817
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(Gfap-gp120)10Lms/0 involves: C57BL/6 * SJL MGI:5829825


Genotype
MGI:5829825
tg1
Allelic
Composition		 Tg(Gfap-gp120)10Lms/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
microgliosis ( J:146427 )
• mice exhibit increased number of F4/80+ microglial cells that display increased branching and cytoplasmic distension, suggesting microglial activation
astrocytosis ( J:146427 )
• widespread reactive astrocytosis
abnormal dendrite morphology ( J:146427 )
• extensive vacuolizations of dendrites
abnormal synapse morphology ( J:146427 )
• decrease in synpato-dendritic complexity
neuron degeneration ( J:146427 )
• loss of large pyramidal neurons

immune system
microgliosis ( J:146427 )
• mice exhibit increased number of F4/80+ microglial cells that display increased branching and cytoplasmic distension, suggesting microglial activation

hematopoietic system
microgliosis ( J:146427 )
• mice exhibit increased number of F4/80+ microglial cells that display increased branching and cytoplasmic distension, suggesting microglial activation




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory