Phenotypes associated with this allele

• Allele Symbol: Tg(Pomc-cre)1Lowl
• Allele Name: transgene insertion 1, Bradford B Lowell
• Allele ID: MGI:4362028
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mical1^tm1.1Past/Mical1^tm1.1Past Tg(Pomc-cre)1Lowl/0	involves: 129 * FVB	MGI:7628686
cn2	Grin1^tm2Stl/Grin1^tm2Stl Tg(Pomc-cre)1Lowl/0	involves: 129S4/SvJae * C57BL/6 * FVB	MGI:4362041
cn3	Drd5^tm1.1Stl/Drd5^tm1.1Stl Tg(Pomc-cre)1Lowl/0	involves: C57BL/6 * FVB/N	MGI:5603927
cn4	Drd1^tm2.1Stl/Drd1^tm2.1Stl Tg(Pomc-cre)1Lowl/0	involves: C57BL/6 * FVB/N	MGI:5603928

Genotype
MGI:7628686

cn1

• Allelic Composition: Mical1^tm1.1Past/Mical1^tm1.1Past; Tg(Pomc-cre)1Lowl/0
• Genetic Background: involves: 129 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:240378 )

N • no obvious defects in mossy fiber projections or CA3 layering are seen in P55 mice

Genotype
MGI:4362041

cn2

• Allelic Composition: Grin1^tm2Stl/Grin1^tm2Stl; Tg(Pomc-cre)1Lowl/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

nervous system

nervous system phenotype ( J:122763 )

N • population responses recordings from the stimulated perforant path in the dentate hilus are not different from controls at 20-24 weeks

N • paired-pulse facilitation is normal

N • long term potentiation in area CA1 after Schaffer commissural input stimulation in CA3

N • hippocampal memory and discrimination is normal in mutants (measured by acquisition of contextual fear conditioning)

impaired synaptic plasticity ( J:122763 )

• theta-burst stimulation of the perforant path (PP) did not evoke potentiation (plasticity) of synapses of the PP-GC (dentate gyrus granule cells)

behavior/neurological

behavior/neurological phenotype ( J:122763 )

N • open field activity is not different from controls

N • no differences are seen in feeding behavior or body weights compared to controls

N • spatial learning in Morris water maze test is normal

abnormal discrimination learning ( J:122763 )

• mice show impaired acquisition of a discrimination task compared to controls; deficit is limited to early days of training, but is comparable to controls after extended training

Genotype
MGI:5603927

cn3

• Allelic Composition: Drd5^tm1.1Stl/Drd5^tm1.1Stl; Tg(Pomc-cre)1Lowl/0
• Genetic Background: involves: C57BL/6 * FVB/N

behavior/neurological

behavior/neurological phenotype ( J:211355 )

N • mice exhibit normal contextual fear memory, in contrast to mice carrying the Drd1a^tm2.1 allele

Genotype
MGI:5603928

cn4

• Allelic Composition: Drd1^tm2.1Stl/Drd1^tm2.1Stl; Tg(Pomc-cre)1Lowl/0
• Genetic Background: involves: C57BL/6 * FVB/N

behavior/neurological

impaired contextual conditioning behavior ( J:211355 )

• mice exhibit deficits in contextual fear conditioning

• mice exhibit impaired fear memory in 24 hour contextual memory test at multiple time points as compared to control, however, mice exhibit normal cued fear conditioning during tone presentation and have a normal short term memory fear response

• mice exhibit similar fear response between two similar but different contexts, in contrast, controls freeze more in the original (shock) context than in the similar context

decreased fear-related response ( J:211355 )