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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wastm1Itl
targeted mutation 1, inGenious Targeting Laboratory
MGI:4362083
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wastm1Itl/Wastm1Itl Not Specified MGI:4365296
ot2
 		Wastm1Itl/Y Not Specified MGI:4365297


Genotype
MGI:4365296
hm1
Allelic
Composition		 Wastm1Itl/Wastm1Itl
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wastm1Itl mutation (0 available); any Was mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell morphology ( J:153247 )
• bone marrow-derived dendritic cells form fewer podosomes with decreased turnover rates compared with wild-type cells
abnormal lymphocyte morphology ( J:153247 )
• the proportion of mature marginal zone to marginal zone precursors and T2 cells is decreased compared to in wild-type mice
increased B cell number ( J:153247 )
• mice exhibit an increase in B220+ B cells in the spleen compared with wild-type mice
decreased NK cell number ( J:153247 )
• in the spleen
decreased T cell number ( J:153247 )
• mice have fewer CD4+ CD3+ and CD8+ CD3+ T cells than in wild-type mice
• fewer CD3+ T cells, especially CD8+CD3+ and CD4+CD8+Cd3+ T cells, are observed in the spleen, lymph nodes, and thymus than in wild-type mice
abnormal dendritic cell physiology ( J:153247 )
• chemotaxis velocity of bone marrow-derived dendritic cells in response to CCL3 is decreased compared to similarly treated wild-type cells but not as much as in cells from Wastm2Igl or Wastm1Sbs homozygotes
• migration of dendritic cells is impaired compared to wild-type cells
• dendritic cells fail to exhibit an increase in phagocytosis of latex beads unlike similarly treated wild-type cells

hematopoietic system
abnormal dendritic cell morphology ( J:153247 )
• bone marrow-derived dendritic cells form fewer podosomes with decreased turnover rates compared with wild-type cells
abnormal lymphocyte morphology ( J:153247 )
• the proportion of mature marginal zone to marginal zone precursors and T2 cells is decreased compared to in wild-type mice
increased B cell number ( J:153247 )
• mice exhibit an increase in B220+ B cells in the spleen compared with wild-type mice
decreased NK cell number ( J:153247 )
• in the spleen
decreased T cell number ( J:153247 )
• mice have fewer CD4+ CD3+ and CD8+ CD3+ T cells than in wild-type mice
• fewer CD3+ T cells, especially CD8+CD3+ and CD4+CD8+Cd3+ T cells, are observed in the spleen, lymph nodes, and thymus than in wild-type mice

cellular

growth/size/body
spleen hyperplasia ( J:153247 )




Genotype
MGI:4365297
ot2
Allelic
Composition		 Wastm1Itl/Y
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wastm1Itl mutation (0 available); any Was mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell morphology ( J:153247 )
• bone marrow-derived dendritic cells form fewer podosomes with decreased turnover rates compared with wild-type cells
abnormal lymphocyte morphology ( J:153247 )
• the proportion of mature marginal zone to marginal zone precursors and T2 cells is decreased compared to in wild-type mice
increased B cell number ( J:153247 )
• mice exhibit an increase in B220+ B cells in the spleen compared with wild-type mice
decreased NK cell number ( J:153247 )
• in the spleen
decreased T cell number ( J:153247 )
• mice have fewer CD4+ CD3+ and CD8+ CD3+ T cells than in wild-type mice
• fewer CD3+ T cells, especially CD8+CD3+ and CD4+CD8+Cd3+ T cells, are observed in the spleen, lymph nodes, and thymus than in wild-type mice
abnormal dendritic cell physiology ( J:153247 )
• chemotaxis velocity of bone marrow-derived dendritic cells in response to CCL3 is decreased compared to similarly treated wild-type cells but not as much as in cells from Wastm2Igl or Wastm1Sbs homozygotes
• migration of dendritic cells is impaired compared to wild-type cells
• dendritic cells fail to exhibit an increase in phagocytosis of latex beads unlike similarly treated wild-type cells

hematopoietic system
abnormal dendritic cell morphology ( J:153247 )
• bone marrow-derived dendritic cells form fewer podosomes with decreased turnover rates compared with wild-type cells
abnormal lymphocyte morphology ( J:153247 )
• the proportion of mature marginal zone to marginal zone precursors and T2 cells is decreased compared to in wild-type mice
increased B cell number ( J:153247 )
• mice exhibit an increase in B220+ B cells in the spleen compared with wild-type mice
decreased NK cell number ( J:153247 )
• in the spleen
decreased T cell number ( J:153247 )
• mice have fewer CD4+ CD3+ and CD8+ CD3+ T cells than in wild-type mice
• fewer CD3+ T cells, especially CD8+CD3+ and CD4+CD8+Cd3+ T cells, are observed in the spleen, lymph nodes, and thymus than in wild-type mice

growth/size/body
spleen hyperplasia ( J:153247 )

cellular




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory