All Phenotypes Was<tm2Itl> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Was^tm2Itl/Was^tm2Itl	Not Specified	MGI:4365299
ot2	Was^tm2Itl/Y	Not Specified	MGI:4365298

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T cell proliferation ( J:153247 )

thrombocytopenia ( J:153247 )

increased leukocyte cell number ( J:153247 )

abnormal dendritic cell morphology ( J:153247 )

• bone marrow-derived dendritic cells form fewer podosomes with decreased turnover rates compared with wild-type cells

abnormal lymphocyte morphology ( J:153247 )

• the proportion of mature marginal zone to marginal zone precursors and T2 cells is decreased compared to in wild-type mice

increased B cell number ( J:153247 )

• mice exhibit an increase in B220+ B cells in the spleen compared with wild-type mice

increased follicular B cell number ( J:153247 )

decreased NK cell number ( J:153247 )

• in the spleen

decreased T cell number ( J:153247 )

• mice have fewer CD4+ CD3+ and CD8+ CD3+ T cells than in wild-type mice

• fewer CD3+ T cells, especially CD8+CD3+ and CD4+CD8+Cd3+ T cells, are observed in the spleen, lymph nodes, and thymus than in wild-type mice

increased splenocyte number ( J:153247 )

immune system

decreased T cell proliferation ( J:153247 )

increased leukocyte cell number ( J:153247 )

abnormal dendritic cell morphology ( J:153247 )

• bone marrow-derived dendritic cells form fewer podosomes with decreased turnover rates compared with wild-type cells

abnormal lymphocyte morphology ( J:153247 )

• the proportion of mature marginal zone to marginal zone precursors and T2 cells is decreased compared to in wild-type mice

increased B cell number ( J:153247 )

• mice exhibit an increase in B220+ B cells in the spleen compared with wild-type mice

increased follicular B cell number ( J:153247 )

decreased NK cell number ( J:153247 )

• in the spleen

decreased T cell number ( J:153247 )

• mice have fewer CD4+ CD3+ and CD8+ CD3+ T cells than in wild-type mice

• fewer CD3+ T cells, especially CD8+CD3+ and CD4+CD8+Cd3+ T cells, are observed in the spleen, lymph nodes, and thymus than in wild-type mice

increased splenocyte number ( J:153247 )

abnormal dendritic cell physiology ( J:153247 )

• chemotaxis velocity of bone marrow-derived dendritic cells in response to CCL3 is decreased compared to similarly treated wild-type cells

• migration of dendritic cells is impaired compared to wild-type cells

• dendritic cells fail to exhibit an increase in phagocytosis of latex beads unlike similarly treated wild-type cells

increased anti-double stranded DNA antibody level ( J:153247 )

• at a low titer

cellular

decreased T cell proliferation ( J:153247 )

Allelic Composition	Was^tm2Itl/Y
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Was^tm2Itl mutation (0 available); any Was mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T cell proliferation ( J:153247 )

thrombocytopenia ( J:153247 )

increased leukocyte cell number ( J:153247 )

abnormal dendritic cell morphology ( J:153247 )

• bone marrow-derived dendritic cells form fewer podosomes with decreased turnover rates compared with wild-type cells

abnormal lymphocyte morphology ( J:153247 )

• the proportion of mature marginal zone to marginal zone precursors and T2 cells is decreased compared to in wild-type mice

increased B cell number ( J:153247 )

• mice exhibit an increase in B220+ B cells in the spleen compared with wild-type mice

increased follicular B cell number ( J:153247 )

decreased NK cell number ( J:153247 )

• in the spleen

decreased T cell number ( J:153247 )

• mice have fewer CD4+ CD3+ and CD8+ CD3+ T cells than in wild-type mice

• fewer CD3+ T cells, especially CD8+CD3+ and CD4+CD8+Cd3+ T cells, are observed in the spleen, lymph nodes, and thymus than in wild-type mice

increased splenocyte number ( J:153247 )

immune system

decreased T cell proliferation ( J:153247 )

increased leukocyte cell number ( J:153247 )

abnormal dendritic cell morphology ( J:153247 )

• bone marrow-derived dendritic cells form fewer podosomes with decreased turnover rates compared with wild-type cells

abnormal lymphocyte morphology ( J:153247 )

• the proportion of mature marginal zone to marginal zone precursors and T2 cells is decreased compared to in wild-type mice

increased B cell number ( J:153247 )

• mice exhibit an increase in B220+ B cells in the spleen compared with wild-type mice

increased follicular B cell number ( J:153247 )

decreased NK cell number ( J:153247 )

• in the spleen

decreased T cell number ( J:153247 )

• mice have fewer CD4+ CD3+ and CD8+ CD3+ T cells than in wild-type mice

• fewer CD3+ T cells, especially CD8+CD3+ and CD4+CD8+Cd3+ T cells, are observed in the spleen, lymph nodes, and thymus than in wild-type mice

increased splenocyte number ( J:153247 )

abnormal dendritic cell physiology ( J:153247 )

• chemotaxis velocity of bone marrow-derived dendritic cells in response to CCL3 is decreased compared to similarly treated wild-type cells

• migration of dendritic cells is impaired compared to wild-type cells

• dendritic cells fail to exhibit an increase in phagocytosis of latex beads unlike similarly treated wild-type cells

increased anti-double stranded DNA antibody level ( J:153247 )

• at a low titer

cellular

decreased T cell proliferation ( J:153247 )

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