Phenotypes associated with this allele

• Allele Symbol: Sphk2^tm1.1Stlp
• Allele Name: targeted mutation 1.1, Stanford L Peng
• Allele ID: MGI:4362092
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sphk2^tm1.1Stlp/Sphk2^tm1.1Stlp	involves: BALB/c	MGI:4362093

Genotype
MGI:4362093

hm1

• Allelic Composition: Sphk2^tm1.1Stlp/Sphk2^tm1.1Stlp
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:153014 )

• CD4 positive T cells exhibit a hyperactivated phenotype with significantly enhanced proliferation and cytokine secretion in response to IL-2 as well as reduced sensitivity to regulatory T cell-mediated suppression in vitro

• mice were viable, fertile, exhibited apparently normal longevity, and lacked overt abnormalities

• cellularities and fractional distributions of major lymphocyte subsets were not significantly affected

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:153014 )

• CD4 positive T cells exhibit a hyperactivated phenotype with significantly enhanced proliferation and cytokine secretion in response to IL-2 as well as reduced sensitivity to regulatory T cell-mediated suppression in vitro

• mice were viable, fertile, exhibited apparently normal longevity, and lacked overt abnormalities

• cellularities and fractional distributions of major lymphocyte subsets were not significantly affected